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Brief Report

Monoclonal Antibodies against SARS-CoV-2: Potential Game-Changer Still Underused

1
Section of Infectious Diseases, Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy
2
Staff UNESCO Chair on Health Education and Sustainable Development, University of Naples Federico II, 80131 Naples, Italy
3
First Division of Infectious Diseases, Cotugno Hospital, AORN Dei Colli, 80131 Naples, Italy
4
Euro Mediterranean Scientific Biomedical Institute, 1000 Bruxelles, Belgium
5
Department of Environmental Science and Policy, University of Milan, 20122 Milan, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2021, 18(21), 11159; https://doi.org/10.3390/ijerph182111159
Received: 27 September 2021 / Revised: 20 October 2021 / Accepted: 21 October 2021 / Published: 24 October 2021
(This article belongs to the Special Issue COVID-19: COVID-19 Epidemiological and Clinical Challenges)
Even several months after the start of a massive vaccination campaign against COVID-19, mortality and hospital admission are still high in many countries. Monoclonal antibodies against SARS-CoV-2 are the ideal complement to vaccination in infected subjects who are at high risk for progression to severe disease. Based on data of the Italian Ministry of Health, in the period April–August 2021, monoclonal antibodies were prescribed to 6322 patients. In the same period, 70,022 patients over 70 years old became infected with SARS-CoV-2. Even considering that all monoclonal antibodies were prescribed to this category of patients, we calculated that only 9% of these subjects received the treatment. Moreover, using efficacy data provided by clinal trials, we estimated the potential benefit in terms of reduction of hospital admissions and deaths. Considering utilisation of monoclonal antibodies in half infected patients over 70 years, we estimated that hospital admissions and deaths might have been reduced by 7666 and 3507, respectively. Finally, we calculated the economic benefit of monoclonal use. In the same scenario (50% use of monoclonal antibodies to patients over 70), we estimated potential savings of USD 117,410,105. In conclusion, monoclonal antibodies were used in a small proportion of patients over 70 in Italy. A more extensive use might have resulted in a marked decrease in hospital admissions, deaths and in conspicuous saving for the health system. View Full-Text
Keywords: COVID-19; monoclonal antibodies; lethality; hospitalizations; savings COVID-19; monoclonal antibodies; lethality; hospitalizations; savings
MDPI and ACS Style

Gentile, I.; Maraolo, A.E.; Buonomo, A.R.; Nobile, M.; Piscitelli, P.; Miani, A.; Schiano Moriello, N. Monoclonal Antibodies against SARS-CoV-2: Potential Game-Changer Still Underused. Int. J. Environ. Res. Public Health 2021, 18, 11159. https://doi.org/10.3390/ijerph182111159

AMA Style

Gentile I, Maraolo AE, Buonomo AR, Nobile M, Piscitelli P, Miani A, Schiano Moriello N. Monoclonal Antibodies against SARS-CoV-2: Potential Game-Changer Still Underused. International Journal of Environmental Research and Public Health. 2021; 18(21):11159. https://doi.org/10.3390/ijerph182111159

Chicago/Turabian Style

Gentile, Ivan, Alberto E. Maraolo, Antonio R. Buonomo, Mariano Nobile, Prisco Piscitelli, Alessandro Miani, and Nicola Schiano Moriello. 2021. "Monoclonal Antibodies against SARS-CoV-2: Potential Game-Changer Still Underused" International Journal of Environmental Research and Public Health 18, no. 21: 11159. https://doi.org/10.3390/ijerph182111159

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