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Review

A Systematic Review of Characteristics Associated with COVID-19 in Children with Typical Presentation and with Multisystem Inflammatory Syndrome

1
Division of Neurology, New Jersey Pediatric Neuroscience Institute (NJPNI), Morristown, NJ 07960, USA
2
Department of Neurology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA
3
College of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA
4
Department of Biology, The College of New Jersey, Ewing, NJ 08628, USA
5
School of Arts and Sciences, Rutgers University, New Brunswick, NJ 08901, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Anthony R. Mawson and Jitse P. van Dijk
Int. J. Environ. Res. Public Health 2021, 18(16), 8269; https://doi.org/10.3390/ijerph18168269
Received: 9 July 2021 / Revised: 26 July 2021 / Accepted: 27 July 2021 / Published: 4 August 2021
(This article belongs to the Special Issue Review Papers in Children’s Health)
Setting off a global pandemic, coronavirus disease 2019 (COVID-19) has been marked by a heterogeneous clinical presentation that runs the gamut from asymptomatic to severe and fatal. Although less lethal in children than adults, COVID-19 has nonetheless afflicted the pediatric population. This systematic review used clinical information from published literature to assess the spectrum of COVID-19 presentation in children, with special emphasis on characteristics associated with multisystem inflammatory syndrome (MIS-C). An electronic literature search for English and Chinese language articles in COVIDSeer, MEDLINE, and PubMed from 1 January 2020 through 1 March 2021 returned 579 records, of which 54 were included for full evaluation. Out of the total 4811 patients, 543 (11.29%) exhibited MIS-C. The most common symptoms across all children were fever and sore throat. Children presenting with MIS-C were less likely to exhibit sore throat and respiratory symptoms (i.e., cough, shortness of breath) compared to children without MIS-C. Inflammatory (e.g., rash, fever, and weakness) and gastrointestinal (e.g., nausea/vomiting and diarrhea) symptoms were present to a greater extent in children with both COVID-19 and MIS-C, suggesting that children testing positive for COVID-19 and exhibiting such symptoms should be evaluated for MIS-C. View Full-Text
Keywords: Kawasaki-like; hyperinflammation; anosmia; lymphocytopenia; SARS-CoV-2; MIS-C Kawasaki-like; hyperinflammation; anosmia; lymphocytopenia; SARS-CoV-2; MIS-C
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MDPI and ACS Style

Kornitzer, J.; Johnson, J.; Yang, M.; Pecor, K.W.; Cohen, N.; Jiang, C.; Ming, X. A Systematic Review of Characteristics Associated with COVID-19 in Children with Typical Presentation and with Multisystem Inflammatory Syndrome. Int. J. Environ. Res. Public Health 2021, 18, 8269. https://doi.org/10.3390/ijerph18168269

AMA Style

Kornitzer J, Johnson J, Yang M, Pecor KW, Cohen N, Jiang C, Ming X. A Systematic Review of Characteristics Associated with COVID-19 in Children with Typical Presentation and with Multisystem Inflammatory Syndrome. International Journal of Environmental Research and Public Health. 2021; 18(16):8269. https://doi.org/10.3390/ijerph18168269

Chicago/Turabian Style

Kornitzer, Jeffrey, Jacklyn Johnson, Max Yang, Keith W. Pecor, Nicholas Cohen, Carolyn Jiang, and Xue Ming. 2021. "A Systematic Review of Characteristics Associated with COVID-19 in Children with Typical Presentation and with Multisystem Inflammatory Syndrome" International Journal of Environmental Research and Public Health 18, no. 16: 8269. https://doi.org/10.3390/ijerph18168269

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