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Article

Maternal Ambient Exposure to Atmospheric Pollutants during Pregnancy and Offspring Term Birth Weight in the Nationwide ELFE Cohort

1
Univ. Grenoble Alpes, Inserm, CNRS, IAB, 38000 Grenoble, France
2
Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
3
ASPA, ATMO Grand Est, 67300 Schiltigheim, France
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Ined-Inserm-EFS Joint Unit ELFE, 75020 Paris, France
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ATMO Normandie, 76000 Rouen, France
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AIR Pays-de-la-Loire, 44300 Nantes, France
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AIRPARIF, 75004 Paris, France
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ATMO Nouvelle-Aquitaine, 33000 Bordeaux, France
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Department of Geography and Environmental Development, Ben-Gurion University of the Negev, Beer Sheva P.O. Box 653, Israel
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ATMO France, 75004 Paris, France
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U1086 INSERM-UCN ‘Anticipe’, 14000 Caen, France
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National Institute for Industrial Environment and Risks (INERIS), 60550 Verneuil en Halatte, France
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ATMO Occitanie, 31330 Toulouse, France
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Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA
15
ATMO PACA, 13006 Marseille, France
16
Inserm Univ. Paris Descartes, U1153 CRESS, 75004 Paris, France
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2021, 18(11), 5806; https://doi.org/10.3390/ijerph18115806
Received: 28 April 2021 / Revised: 18 May 2021 / Accepted: 20 May 2021 / Published: 28 May 2021
(This article belongs to the Special Issue The Ambient Environment and Reproductive Health)
Background: Studies have reported associations between maternal exposure to atmospheric pollution and lower birth weight. However, the evidence is not consistent and uncertainties remain. We used advanced statistical approaches to robustly estimate the association of atmospheric pollutant exposure during specific pregnancy time windows with term birth weight (TBW) in a nationwide study. Methods: Among 13,334 women from the French Longitudinal Study of Children (ELFE) cohort, exposures to PM2.5, PM10 (particles < 2.5 µm and <10 µm) and NO2 (nitrogen dioxide) were estimated using a fine spatio-temporal exposure model. We used inverse probability scores and doubly robust methods in generalized additive models accounting for spatial autocorrelation to study the association of such exposures with TBW. Results: First trimester exposures were associated with an increased TBW. Second trimester exposures were associated with a decreased TBW by 17.1 g (95% CI, −26.8, −7.3) and by 18.0 g (−26.6, −9.4) for each 5 µg/m3 increase in PM2.5 and PM10, respectively, and by 15.9 g (−27.6, −4.2) for each 10 µg/m3 increase in NO2. Third trimester exposures (truncated at 37 gestational weeks) were associated with a decreased TBW by 48.1 g (−58.1, −38.0) for PM2.5, 38.1 g (−46.7, −29.6) for PM10 and 14.7 g (−25.3, −4.0) for NO2. Effects of pollutants on TBW were larger in rural areas. Conclusions: Our results support an adverse effect of air pollutant exposure on TBW. We highlighted a larger effect of air pollutants on TBW among women living in rural areas compared to women living in urban areas. View Full-Text
Keywords: air pollution; term birth weight; spatial autocorrelation; propensity score; doubly robust air pollution; term birth weight; spatial autocorrelation; propensity score; doubly robust
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MDPI and ACS Style

Ouidir, M.; Seyve, E.; Rivière, E.; Bernard, J.; Cheminat, M.; Cortinovis, J.; Ducroz, F.; Dugay, F.; Hulin, A.; Kloog, I.; Laborie, A.; Launay, L.; Malherbe, L.; Robic, P.-Y.; Schwartz, J.; Siroux, V.; Virga, J.; Zaros, C.; Charles, M.-A.; Slama, R.; Lepeule, J. Maternal Ambient Exposure to Atmospheric Pollutants during Pregnancy and Offspring Term Birth Weight in the Nationwide ELFE Cohort. Int. J. Environ. Res. Public Health 2021, 18, 5806. https://doi.org/10.3390/ijerph18115806

AMA Style

Ouidir M, Seyve E, Rivière E, Bernard J, Cheminat M, Cortinovis J, Ducroz F, Dugay F, Hulin A, Kloog I, Laborie A, Launay L, Malherbe L, Robic P-Y, Schwartz J, Siroux V, Virga J, Zaros C, Charles M-A, Slama R, Lepeule J. Maternal Ambient Exposure to Atmospheric Pollutants during Pregnancy and Offspring Term Birth Weight in the Nationwide ELFE Cohort. International Journal of Environmental Research and Public Health. 2021; 18(11):5806. https://doi.org/10.3390/ijerph18115806

Chicago/Turabian Style

Ouidir, Marion, Emie Seyve, Emmanuel Rivière, Julien Bernard, Marie Cheminat, Jérôme Cortinovis, François Ducroz, Fabrice Dugay, Agnès Hulin, Itai Kloog, Anne Laborie, Ludivine Launay, Laure Malherbe, Pierre-Yves Robic, Joel Schwartz, Valérie Siroux, Jonathan Virga, Cécile Zaros, Marie-Aline Charles, Rémy Slama, and Johanna Lepeule. 2021. "Maternal Ambient Exposure to Atmospheric Pollutants during Pregnancy and Offspring Term Birth Weight in the Nationwide ELFE Cohort" International Journal of Environmental Research and Public Health 18, no. 11: 5806. https://doi.org/10.3390/ijerph18115806

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