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Article

Association between Blood Group and Nonmelanoma Skin Cancers (Basal Cell Carcinoma and Squamous Cell Carcinoma)

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Medikol Polyclinic, Franca Prešerna 13, 40 000 Čakovec, Croatia
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Croatian Academy of Medical Sciences, Praška 2, 10 000 Zagreb, Croatia
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Faculty of Medicine, University of Rijeka, Braće Branchetta 20/1, 51 000 Rijeka, Croatia
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Andrija Štampar Teaching Institute of Public Health, Mirogojska cesta 16, 10 000 Zagreb, Croatia
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Čakovec County Hospital, Ivana Gorana Kovačića 1E, 40 000 Čakovec, Croatia
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2019, 16(13), 2267; https://doi.org/10.3390/ijerph16132267
Received: 11 May 2019 / Revised: 23 June 2019 / Accepted: 25 June 2019 / Published: 27 June 2019
(This article belongs to the Section Global Health)
Background: Development of nonmelanoma skin cancers (NMSCs) has been associated with certain risk factors, but studies of the association between ABO blood group and NMSCs have been rare and inconclusive. The aim of this study was to assess the association of the previously known risk factors and blood group as a new potential risk factor in NMSCs. Methods: The study included 401 patients, 202 men, and 199 women, which included 367 diagnosed cases of basal cell carcinoma and 148 diagnosed cases of squamous cell carcinoma. The control group consisted of 438 subjects, 198 men, and 240 women. A standardized questionnaire adapted for this targeted study was used. The relation between the dependent variable (NMSCs) and independent variables was investigated by logistic regression. Results: Compared to the non AB blood group, the risk of developing NMSCs was significantly higher in the AB blood group (MOR = 2.28; 95% CI = 1.41–3.69). We established a logistic model that could best describe the probability of NMSCs development. Conclusion: Study results are expected to instigate basic research into the role of A and B antigens in normal skin epithelium, NMSCs etiopathogenesis, possible effect on metastatic potential and disease prognosis, potential tumor immunotherapy, and targeted detection and prevention in subjects at an increased risk of NMSCs development. View Full-Text
Keywords: ABO blood groups; nonmelanoma skin cancers; basal cell carcinoma; squamous cell carcinoma ABO blood groups; nonmelanoma skin cancers; basal cell carcinoma; squamous cell carcinoma
MDPI and ACS Style

Celić, D.; Lipozenčić, J.; Kolarić, B.; Ferenčak, G.; Rajković, J.K.; Borlinić, T. Association between Blood Group and Nonmelanoma Skin Cancers (Basal Cell Carcinoma and Squamous Cell Carcinoma). Int. J. Environ. Res. Public Health 2019, 16, 2267. https://doi.org/10.3390/ijerph16132267

AMA Style

Celić D, Lipozenčić J, Kolarić B, Ferenčak G, Rajković JK, Borlinić T. Association between Blood Group and Nonmelanoma Skin Cancers (Basal Cell Carcinoma and Squamous Cell Carcinoma). International Journal of Environmental Research and Public Health. 2019; 16(13):2267. https://doi.org/10.3390/ijerph16132267

Chicago/Turabian Style

Celić, Dijana, Jasna Lipozenčić, Branko Kolarić, Goran Ferenčak, Jolanda K. Rajković, and Tajana Borlinić. 2019. "Association between Blood Group and Nonmelanoma Skin Cancers (Basal Cell Carcinoma and Squamous Cell Carcinoma)" International Journal of Environmental Research and Public Health 16, no. 13: 2267. https://doi.org/10.3390/ijerph16132267

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