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Molecular Evolution of Multiple Arylalkylamine N-Acetyltransferase (AANAT) in Fish

Antiprotozoal Activities of Organic Extracts from French Marine Seaweeds

Pharmacognosie et Molécules Naturelles Bio-actives, Laboratoire d’Innovation Thérapeutique UMR CNRS 7200, Faculté de Pharmacie, Université de Strasbourg, 74 route du Rhin, 67401 Illkirch cedex, France
Physiologie et Ecophysiologie des Mollusques Marins, UMR M IFREMER 100, Institut de Biologie Fondamentale et Appliquée (IBFA), Université de Caen Basse-Normandie, 14032 Caen cedex, France
Swiss Tropical and Public Health Institution, Socinstrasse 57, 4002 Basel, Switzerland
University of Basel, Petersplatz 1, 4003 Basel, Switzerland
Author to whom correspondence should be addressed.
Mar. Drugs 2011, 9(6), 922-933;
Received: 6 April 2011 / Revised: 13 May 2011 / Accepted: 23 May 2011 / Published: 25 May 2011
Marine macrophytes contain a variety of biologically active compounds, some reported to have antiprotozoal activity in vitro. As a part of a screening program to search for new natural antiprotozoals, we screened hydroalcoholic and ethyl acetate extracts of 20 species of seaweeds from three phyla (Rhodophyta, Heterokontophyta and Chlorophyta), sampled along the Normandy (France) coast. We tested them in vitro against the protozoa responsible for three major endemic parasitic diseases: Plasmodium falciparum, Leishmania donovani and Trypanosoma cruzi. The selectivity of the extracts was also evaluated by testing on a mammalian cell line (L6 cells). Ethyl acetate extracts were more active than hydroalcoholic ones. Activity against T. cruzi and L. donovani was non-existent to average, but almost half the extracts showed good activity against P. falciparum. The ethyl acetate extract of Mastocarpus stellatus showed the best antiplasmodial activity as well as the best selectivity index (IC50 = 2.8 µg/mL; SI > 30). Interestingly, a red algae species, which shares phylogenetic origins with P. falciparum, showed the best antiplasmodial activity. This study is the first to report comparative antiprotozoal activity of French marine algae. Some of the species studied here have not previously been biologically evaluated. View Full-Text
Keywords: seaweeds; Phaeophyceae; Rhodophyceae; Plasmodium; Trypanosoma; Leishmania seaweeds; Phaeophyceae; Rhodophyceae; Plasmodium; Trypanosoma; Leishmania
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MDPI and ACS Style

Vonthron-Sénécheau, C.; Kaiser, M.; Devambez, I.; Vastel, A.; Mussio, I.; Rusig, A.-M. Antiprotozoal Activities of Organic Extracts from French Marine Seaweeds. Mar. Drugs 2011, 9, 922-933.

AMA Style

Vonthron-Sénécheau C, Kaiser M, Devambez I, Vastel A, Mussio I, Rusig A-M. Antiprotozoal Activities of Organic Extracts from French Marine Seaweeds. Marine Drugs. 2011; 9(6):922-933.

Chicago/Turabian Style

Vonthron-Sénécheau, Catherine, Marcel Kaiser, Isabelle Devambez, Antoine Vastel, Isabelle Mussio, and Anne-Marie Rusig. 2011. "Antiprotozoal Activities of Organic Extracts from French Marine Seaweeds" Marine Drugs 9, no. 6: 922-933.

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