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Volume 21
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10.3390/md21090468
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Article

Anti-Hyperlipidemic Effect of Fucoidan Fractions Prepared from Iceland Brown Algae Ascophyllum nodosum in an Hyperlipidemic Mice Model

by
Yunhai He
1,2,3,4,*,
Yutong Li
1,3,4,
Peili Shen
2,*,
Shangkun Li
1,3,4,
Linsong Zhang
1,3,4,
Qiukuan Wang
1,3,4,
Dandan Ren
1,3,4,
Shu Liu
1,3,4,
Demeng Zhang
2 and
Hui Zhou
1,3,4
1
College of Food Science and Engineering, Dalian Ocean University, Dalian 116023, China
2
State Key Laboratory of Marine Food Processing & Safety Control, Qingdao Bright Moon Seaweed Group Co., Ltd., Qingdao 266400, China
3
Key Laboratory of Aquatic Product Processing and Utilization of Liaoning Province, Dalian Ocean University, Dalian 116023, China
4
National R&D Branch Center for Seaweed Processing, Dalian Ocean University, Dalian 116023, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2023, 21(9), 468; https://doi.org/10.3390/md21090468
Submission received: 23 June 2023 / Revised: 22 August 2023 / Accepted: 22 August 2023 / Published: 26 August 2023
(This article belongs to the Special Issue Biomedical Application of Marine-Derived Carbohydrates)
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Abstract

Ascophyllum nodosum, a brown algae abundantly found along the North Atlantic coast, is recognized for its high polysaccharide content. In this study, we investigated the anti-hyperlipidemic effect of fucoidans derived from A. nodosum, aiming to provide information for their potential application in anti-hyperlipidemic therapies and to explore comprehensive utilization of this Iceland brown seaweed. The crude fucoidan prepared from A. nodosum was separated using a diethylethanolamine column, resulting in two fucoidan fractions, AFC-1 and AFC-2. Both fractions were predominantly composed of fucose and xylose. AFC-1 exhibited a higher sulfate content of 27.8% compared to AFC-2 with 17.0%. AFC-2 was primarily sulfated at the hydroxy group of C2, whereas AFC-1 was sulfated at both the hydroxy groups of C2 and C4. To evaluate the anti-hyperlipidemic effect, a hyperlipidemia mouse model was established by feeding mice a high-fat diet. The effects of AFC-1, AFC-2, and the crude extract were investigated, with the drug atorvastatin used as a positive comparison. Among the different fucoidan fractions and doses, the high dose of AFC-2 administration demonstrated the most significant anti-hyperlipidemic effect across various aspects, including physiological parameters, blood glucose levels, lipid profile, histological analysis, and the activities of oxidative stress-related enzymes and lipoprotein-metabolism-related enzymes (p < 0.05 for the final body weight and p < 0.01 for the rest indicators, compared with the model group), and its effect is comparable to the atorvastatin administration. Furthermore, fucoidan administration resulted in a lower degree of loss in gut flora diversity compared to atorvastatin administration. These findings highlight the significant biomedical potential of fucoidans derived from A. nodosum as a promising therapeutic solution for hypolipidemia.
Keywords: Ascophyllum nodosum; fucoidan; anti-hyperlipidemic; antioxidant enzyme; lipoprotein metabolism; gut flora Ascophyllum nodosum; fucoidan; anti-hyperlipidemic; antioxidant enzyme; lipoprotein metabolism; gut flora
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MDPI and ACS Style

He, Y.; Li, Y.; Shen, P.; Li, S.; Zhang, L.; Wang, Q.; Ren, D.; Liu, S.; Zhang, D.; Zhou, H. Anti-Hyperlipidemic Effect of Fucoidan Fractions Prepared from Iceland Brown Algae Ascophyllum nodosum in an Hyperlipidemic Mice Model. Mar. Drugs 2023, 21, 468. https://doi.org/10.3390/md21090468

AMA Style

He Y, Li Y, Shen P, Li S, Zhang L, Wang Q, Ren D, Liu S, Zhang D, Zhou H. Anti-Hyperlipidemic Effect of Fucoidan Fractions Prepared from Iceland Brown Algae Ascophyllum nodosum in an Hyperlipidemic Mice Model. Marine Drugs. 2023; 21(9):468. https://doi.org/10.3390/md21090468

Chicago/Turabian Style

He, Yunhai, Yutong Li, Peili Shen, Shangkun Li, Linsong Zhang, Qiukuan Wang, Dandan Ren, Shu Liu, Demeng Zhang, and Hui Zhou. 2023. "Anti-Hyperlipidemic Effect of Fucoidan Fractions Prepared from Iceland Brown Algae Ascophyllum nodosum in an Hyperlipidemic Mice Model" Marine Drugs 21, no. 9: 468. https://doi.org/10.3390/md21090468

APA Style

He, Y., Li, Y., Shen, P., Li, S., Zhang, L., Wang, Q., Ren, D., Liu, S., Zhang, D., & Zhou, H. (2023). Anti-Hyperlipidemic Effect of Fucoidan Fractions Prepared from Iceland Brown Algae Ascophyllum nodosum in an Hyperlipidemic Mice Model. Marine Drugs, 21(9), 468. https://doi.org/10.3390/md21090468

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