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Open AccessArticle

Sublingual Delivery of Astaxanthin through a Novel Ascorbyl Palmitate-Based Nanoemulsion: Preliminary Data

1
Research and Innovation Technology, Nutraceutical Department, Labomar Research, 31036 Istrana, Italy
2
Medical and Surgical Sciences Department, University of Bologna, 40138 Bologna, Italy
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(9), 508; https://doi.org/10.3390/md17090508
Received: 27 July 2019 / Revised: 21 August 2019 / Accepted: 23 August 2019 / Published: 29 August 2019
(This article belongs to the Collection Marine Carotenoids)
Astaxanthin is a carotenoid extracted from several seaweeds with ascertained therapeutic activity. With specific reference, astaxanthin is widely used in clinical practice to improve ocular tissue health and skin protection from UV ray damages. Despite its well-documented pleiotropic actions and demonstrated clinical efficacy, its bioavailability in humans is low and limited because of its hydrophobicity and poor dissolution in enteric fluids. Furthermore, astaxanthin is very unstable molecule and very sensitive to light exposure and thermal stress. Taken together, these pharmacological and chemical–physical features strongly limit pharmaceutical and nutraceutical development of astaxanthin-based products and as a consequence its full clinical usage. This work describes the preliminary in vitro investigation of sublingual absorption of astaxanthin through a novel ascorbyl palmitate (ASP) based nanoemulsion. View Full-Text
Keywords: astaxanthin; nanoemulsion; sublingual delivery; ascorbyl palmitate; Franz cell astaxanthin; nanoemulsion; sublingual delivery; ascorbyl palmitate; Franz cell
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MDPI and ACS Style

Fratter, A.; Biagi, D.; Cicero, A.F.G. Sublingual Delivery of Astaxanthin through a Novel Ascorbyl Palmitate-Based Nanoemulsion: Preliminary Data. Mar. Drugs 2019, 17, 508.

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