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Marine Drugs
Volume 16
Issue 12
10.3390/md16120508
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Article

Diversity and Ecology of Marine Algicolous Arthrinium Species as a Source of Bioactive Natural Products

by
Young Mok Heo
1,
Kyeongwon Kim
1,
Seung Mok Ryu
2,
Sun Lul Kwon
1,
Min Young Park
2,
Ji Eun Kang
2,
Joo-Hyun Hong
1,
Young Woon Lim
3,
Changmu Kim
4,
Beom Seok Kim
2,
Dongho Lee
2,* and
Jae-Jin Kim
1,*
1
Division of Environmental Science & Ecological Engineering, College of Life Sciences & Biotechnology, Korea University, Seoul 02841, Korea
2
Division of Biotechnology, College of Life Sciences & Biotechnology, Korea University, Seoul 02841, Korea
3
School of Biological Sciences and Institute of Microbiology, Seoul National University, Seoul 08826, Korea
4
Microorganism Resources Division, National Institute of Biological Resources, Incheon 22689, Korea
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2018, 16(12), 508; https://doi.org/10.3390/md16120508
Submission received: 8 November 2018 / Revised: 7 December 2018 / Accepted: 10 December 2018 / Published: 14 December 2018
(This article belongs to the Special Issue Marine Microbial Diversity as a Source of Bioactive Natural Products)
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Abstract

In our previous study, all Arthrinium isolates from Sargassum sp. showed high bioactivities, but studies on marine Arthrinium spp. are insufficient. In this study, a phylogenetic analysis of 28 Arthrinium isolates from seaweeds and egg masses of Arctoscopus japonicus was conducted using internal transcribed spacers, nuclear large subunit rDNA, β-tubulin, and translation elongation factor region sequences, and their bioactivities were investigated. They were analyzed as 15 species, and 11 of them were found to be new species. Most of the extracts exhibited radical-scavenging activity, and some showed antifungal activities, tyrosinase inhibition, and quorum sensing inhibition. It was implied that marine algicolous Arthrinium spp. support the regulation of reactive oxygen species in symbiotic algae and protect against pathogens and bacterial biofilm formation. The antioxidant from Arthrinium sp. 10 KUC21332 was separated by bioassay-guided isolation and identified to be gentisyl alcohol, and the antioxidant of Arthrinium saccharicola KUC21221 was identical. These results demonstrate that many unexploited Arthrinium species still exist in marine environments and that they are a great source of bioactive compounds.
Keywords: antioxidant; biological control; ecological role; gentisyl alcohol; multi-gene phylogeny; tyrosinase inhibition antioxidant; biological control; ecological role; gentisyl alcohol; multi-gene phylogeny; tyrosinase inhibition

Share and Cite

MDPI and ACS Style

Heo, Y.M.; Kim, K.; Ryu, S.M.; Kwon, S.L.; Park, M.Y.; Kang, J.E.; Hong, J.-H.; Lim, Y.W.; Kim, C.; Kim, B.S.; et al. Diversity and Ecology of Marine Algicolous Arthrinium Species as a Source of Bioactive Natural Products. Mar. Drugs 2018, 16, 508. https://doi.org/10.3390/md16120508

AMA Style

Heo YM, Kim K, Ryu SM, Kwon SL, Park MY, Kang JE, Hong J-H, Lim YW, Kim C, Kim BS, et al. Diversity and Ecology of Marine Algicolous Arthrinium Species as a Source of Bioactive Natural Products. Marine Drugs. 2018; 16(12):508. https://doi.org/10.3390/md16120508

Chicago/Turabian Style

Heo, Young Mok, Kyeongwon Kim, Seung Mok Ryu, Sun Lul Kwon, Min Young Park, Ji Eun Kang, Joo-Hyun Hong, Young Woon Lim, Changmu Kim, Beom Seok Kim, and et al. 2018. "Diversity and Ecology of Marine Algicolous Arthrinium Species as a Source of Bioactive Natural Products" Marine Drugs 16, no. 12: 508. https://doi.org/10.3390/md16120508

APA Style

Heo, Y. M., Kim, K., Ryu, S. M., Kwon, S. L., Park, M. Y., Kang, J. E., Hong, J.-H., Lim, Y. W., Kim, C., Kim, B. S., Lee, D., & Kim, J.-J. (2018). Diversity and Ecology of Marine Algicolous Arthrinium Species as a Source of Bioactive Natural Products. Marine Drugs, 16(12), 508. https://doi.org/10.3390/md16120508

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