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Mar. Drugs 2018, 16(11), 436;

Ishophloroglucin A, a Novel Phlorotannin for Standardizing the Anti-α-Glucosidase Activity of Ishige okamurae

Department of Marine Life Science, Jeju National University, Jeju 63243, Korea
Department of Food Bioengineering, Jeju National University, Jeju 63243, Korea
Department of Pharmaceutical Sciences, Changchun University of Chinese Medicine, 1035 Boshuo Road, Jing Yue Economic Development Zone, Chanchun 130117, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 21 September 2018 / Revised: 29 October 2018 / Accepted: 31 October 2018 / Published: 8 November 2018
(This article belongs to the Special Issue Marine Small-Molecule Bioactive Agents and Therapeutic Targets)
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Nutraceutical use of algae requires understanding of the diversity and significance of their active compositions for intended activities. Ishige okamurae (I. okamurae) extract is well-known to possess α-glucosidase inhibitory activity; however, studies are needed to investigate its active composition in order to standardize its α-glucosidase inhibitory activity. In this study, we observed the intensity of the dominant compounds of each I. okamurae extract harvested between 2016 and 2017, and the different potency of each I. okamurae extract against α-glucosidase. By comparing the anti-α-glucosidase ability of the dominant compounds, a novel Ishophloroglucin A with highest α-glucosidase inhibitory activity was identified and suggested for standardization of anti-α-glucosidase activity in I. okamurae extract. Additionally, a validated analytical method for measurement of Ishophloroglucin A for future standardization of I. okamurae extract was established in this study. We suggest using Ishophloroglucin A to standardize anti-α-glucosidase potency of I. okamurae and propose the significance of standardization based on their composition for effective use of algae as marine-derived nutraceuticals. View Full-Text
Keywords: Ishige okamurae; Ishophloroglucin A; α-glucosidase inhibitory activity; validation Ishige okamurae; Ishophloroglucin A; α-glucosidase inhibitory activity; validation

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Ryu, B.; Jiang, Y.; Kim, H.-S.; Hyun, J.-M.; Lim, S.-B.; Li, Y.; Jeon, Y.-J. Ishophloroglucin A, a Novel Phlorotannin for Standardizing the Anti-α-Glucosidase Activity of Ishige okamurae. Mar. Drugs 2018, 16, 436.

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