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Medicina, Volume 58, Issue 7

July 2022 - 138 articles

Cover Story: Biomarkers are necessary for the diagnosis of Alzheimer’s disease (AD) and for advancing clinical trials for AD. The United States Food and Drug Administration (US FDA) has provided guidance for the definition of biomarkers and their contexts of use in drug development, qualitification, and implementation in clinical practice. The Common Alzheimer’s Disease Research Ontology (CADRO) defines known disease processes that comprise therapeutic targets for AD therapies and establishes a framework for AD treatment and biomarker development. Advances in biomarker development promise to provide key foundational information for progress toward new treatments for patients with AD. View this paper
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Articles (138)

  • Case Report
  • Open Access
6 Citations
3,644 Views
9 Pages

19 July 2022

The use of computer-aided rapid prototyping (CARP) models was considered to reduce surgical trauma and improve outcomes when autotransplantation of teeth (ATT) became a viable alternative for dental rehabilitation. However, ATT is considered techniqu...

  • Review
  • Open Access
37 Citations
9,379 Views
21 Pages

19 July 2022

Background and Objectives: The US Food and Drug Administration (FDA) defines a biomarker as a characteristic that is measured as an indicator of normal biological processes, pathogenic processes, or responses to an exposure or intervention. Biomarker...

  • Case Report
  • Open Access
2,357 Views
4 Pages

Epithelioid Rhabdomyosarcoma at the High Parietal Area of the Head: A Case Report

  • Susanne Jung,
  • Lauren Bohner,
  • Miriam Schulte and
  • Johannes Kleinheinz

19 July 2022

Epithelioid rhabdomyosarcoma is a rare condition, which may be clinically misinterpreted as melanoma due to its morphological appearance. Careful morphological and immunohistochemical analysis play an important role in its diagnosis. This case report...

  • Article
  • Open Access
3 Citations
3,730 Views
10 Pages

Bradycardia and Heart Rate Fluctuation Are Associated with a Prolonged Intensive Care Unit Stay in Patients with Severe COVID-19

  • Pattraporn Tajarernmuang,
  • Konlawij Trongtrakul,
  • Warawut Chaiwong,
  • Teerapat Nantsupawat,
  • Athavudh Deesomchok,
  • Panida Chanayat,
  • Nutchanok Niyatiwatchanchai,
  • Theerakorn Theerakittikul,
  • Atikun Limsukon and
  • Chaicharn Pothirat
  • + 2 authors

19 July 2022

Background and Objective: Bradycardia has been observed among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is suspected to be associated with poorer outcomes. Heart rate (HR) fluctuation has been found to be...

  • Review
  • Open Access
7 Citations
3,737 Views
8 Pages

Radiation-Induced Esophageal Cancer: Investigating the Pathogenesis, Management, and Prognosis

  • Athanasios Syllaios,
  • Michail Vailas,
  • Maria Tolia,
  • Nikolaos Charalampakis,
  • Konstantinos Vlachos,
  • Emmanouil I. Kapetanakis,
  • Periklis I. Tomos and
  • Dimitrios Schizas

18 July 2022

One of the most serious late side effects of irradiation is the promotion of tumorigenesis. Radiation-induced esophageal cancer (RIEC) can arise in a previously irradiated field, mostly in patients previously irradiated for thoracic malignancies such...

  • Article
  • Open Access
7 Citations
5,200 Views
13 Pages

Reliability of Isometric Muscle Strength Measurement and Its Accuracy Prediction of Maximal Dynamic Force in People with Multiple Sclerosis

  • Kora Portilla-Cueto,
  • Carlos Medina-Pérez,
  • Ena Monserrat Romero-Pérez,
  • José Aldo Hernández-Murúa,
  • Carolina Vila-Chã and
  • José Antonio de Paz

18 July 2022

Background and Objectives: Multiple sclerosis (MS) is a disease that manifests with varied neurological symptoms, including muscle weakness, especially in the lower extremities. Strength exercises play an important role in the rehabilitation and func...

  • Article
  • Open Access
2,536 Views
8 Pages

The First Evaluation of Proteinase K-Resistant Prion Protein (PrPSc) in Korean Appendix Specimens

  • Sae-Young Won,
  • Yong-Chan Kim,
  • Yu-Ni Lee,
  • Chan-Gyun Park,
  • Woo-Young Kim and
  • Byung-Hoon Jeong

18 July 2022

Background and Objectives: Prion diseases are fatal neurodegenerative disorders caused by the abnormal proteinase K-resistant prion protein (PrPSc). Since variant Creutzfeldt–Jakob disease (CJD) was first reported in the United Kingdom (UK) in...

  • Article
  • Open Access
3 Citations
5,309 Views
9 Pages

Liver Stiffness in Obese Hypothyroid Patients Taking Levothyroxine

  • Roberta Pujia,
  • Elisa Mazza,
  • Tiziana Montalcini,
  • Franco Arturi,
  • Antonio Brunetti,
  • Antonio Aversa,
  • Stefano Romeo,
  • Maria Perticone,
  • Angela Sciacqua and
  • Arturo Pujia

18 July 2022

Background and Objectives: Thyroid dysfunction is associated with non-alcoholic fatty liver disease, but its role in the progression of liver damage in obese patients remains unclear. In addition, several case reports have suggested the existence of...

  • Feature Paper
  • Article
  • Open Access
14 Citations
3,294 Views
12 Pages

Mortality Predictors in Severe SARS-CoV-2 Infection

  • Mihai Lazar,
  • Ecaterina Constanta Barbu,
  • Cristina Emilia Chitu,
  • Ana-Maria-Jennifer Anghel,
  • Cristian-Mihail Niculae,
  • Eliza-Daniela Manea,
  • Anca-Cristina Damalan,
  • Adela-Abigaela Bel,
  • Raluca-Elena Patrascu and
  • Adriana Hristea
  • + 1 author

18 July 2022

Background and Objectives: The severe forms of SARS-CoV-2 pneumonia are associated with acute hypoxic respiratory failure and high mortality rates, raising significant challenges for the medical community. The objective of this paper is to present th...

  • Article
  • Open Access
11 Citations
3,590 Views
10 Pages

17 July 2022

Background and Objectives: Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease that affects predominantly women in the childbearing years. Patients may seek complementary therapies to manage their health and to reduce symptoms...

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Medicina - ISSN 1648-9144