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Current Issues in Molecular Biology, Volume 47, Issue 4

April 2025 - 81 articles

Cover Story: This review provides an in-depth analysis of the mechanisms driving the association between thrombo-inflammatory manifestations and the incidence of RA, the impact of RA treatment on thrombosis prevalence, and potential therapeutic strategies for managing both conditions concurrently. By integrating recent advancements in rheumatoid arthritis (RA) pathophysiology and thrombo-inflammatory research, this paper provides a comprehensive resource on the inflammatory link between RA and thrombosis while discussing and comparing current and emerging treatment approaches. Further investigation into these mechanisms could facilitate the development of targeted therapies that reduce the risk of thrombosis in patients with RA. View this paper
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Articles (81)

  • Article
  • Open Access
1,056 Views
12 Pages

Increased Brain Glutathione Levels by Intranasal Insulin Administration

  • Taisuke Kawashima,
  • Wattanaporn Bhadhprasit,
  • Nobuko Matsumura,
  • Chisato Kinoshita and
  • Koji Aoyama

Background: This paper investigates the effect of intranasal insulin administration on brain glutathione (GSH) levels and elucidates the potential mechanism by which insulin enhances antioxidant defenses in the brain. Methods: C57BL/6J mice were intr...

  • Review
  • Open Access
1,534 Views
14 Pages

Molecular Mechanisms and Potential Therapeutic Targets of Ischemia–Reperfusion Injury in Kidney Transplantation

  • Aaron J. Huang,
  • Gaurav K. Sharma,
  • Rohan Parikh,
  • Zhaosheng Jin,
  • Frank S. Darras and
  • Sergio D. Bergese

End-stage renal disease (ESRD) is a serious and lethal disease that carries with it a high morbidity and mortality rate if left untreated. Treating ESRD is conducted via renal replacement therapy and/or kidney transplantation, with the latter being t...

  • Review
  • Open Access
1,532 Views
28 Pages

The Role of HSP47 in Thrombotic Disorders: Molecular Mechanism and Therapeutic Potential

  • Minodora Teodoru,
  • Oana-Maria Stoia,
  • Maria-Gabriela Vladoiu and
  • Alexandra-Kristine Tonch-Cerbu

This review aims to analyze the role of heat shock protein 47 (HSP47) in thrombosis and evaluate its potential as a therapeutic target for deep vein thrombosis (DVT). A systematic literature review was conducted using PubMed, Scopus, and Web of Scien...

  • Article
  • Open Access
1,162 Views
17 Pages

Associating Patient Responses with Drug Sensitivity in Non-Small Cell Lung Carcinoma Using an Immunoassay on Patient-Derived Cell Cultures

  • Ana Podolski-Renić,
  • Sofija Jovanović Stojanov,
  • Dragana Marić,
  • Jelena Dinić,
  • Miodrag Dragoj,
  • Ana Stepanović,
  • Ema Lupšić,
  • Milica Pajović,
  • Sofija Glumac and
  • Maja Ercegovac
  • + 1 author

Background/Objectives: Non-small cell lung carcinoma (NSCLC) is characterized by its diverse molecular profiles and varying responses to treatment, highlighting the importance of precision medicine in optimizing therapeutic outcomes. A promising appr...

  • Article
  • Open Access
855 Views
12 Pages

Evaluation of miRNA Profile and Its Relationship with Metabolic Disorders in Obese and Pre-Obese Patients

  • Kürşat Kargün,
  • Erhan Aygen,
  • Mehmet Fatih Ebiloğlu,
  • Naci Ömer Alayunt and
  • Lütfiye Kadıoğlu Dalkılıç

Obesity is a growing global public health concern, with its prevalence rapidly increasing in Turkey, leading to severe consequences. Genetic factors, particularly mutations in structural genes and microRNAs (miRNAs) involved in gene expression regula...

  • Article
  • Open Access
1 Citations
1,213 Views
16 Pages

Genome-Wide Association Study (GWAS) on Reproductive Seasonality in Indigenous Greek Sheep Breeds: Insights into Genetic Integrity

  • Danai Antonopoulou,
  • George Symeon,
  • Konstantinos Zaralis,
  • Meni Avdi,
  • Ilias S. Frydas and
  • Ioannis A. Giantsis

A key feature in sheep biology is reproduction seasonality which concerns the cyclical occurrence of natural breeding, which therefore does not take place throughout the year. Since sheep are short-day breeders, the amount of daylight has an impact o...

  • Article
  • Open Access
888 Views
13 Pages

Transient receptor potential vanilloid 3 (TRPV3) is a non-selective cation channel prominently present in the skin. It plays a role in diverse physiological and pathological functions like inflammation of the skin, pain sensations in the skin, and pe...

  • Review
  • Open Access
1 Citations
1,841 Views
19 Pages

Cytokine Therapy in Bladder Cancer: Mechanisms, Efficacy, and Future Prospects

  • Hayden J. Oyler,
  • Layne G. Bruton,
  • Austin J. Maher,
  • Darien A. Yu,
  • Nicholas W. Shely,
  • Mark R. Wakefield and
  • Yujiang Fang

Cytokine therapy is a rapidly evolving field in bladder cancer research, with treatments designed to enhance immune responses, improve targeting, and promote tumor cell recognition and elimination. This review explores pro-inflammatory cytokines, ant...

  • Article
  • Open Access
1 Citations
1,003 Views
9 Pages

A Phylogenetic Analysis Based on Whole Genome Re-Sequencing of 41 Dendrobium Species

  • Feng-Ping Zhang,
  • Xue-Wei Fu,
  • Han-Run Li and
  • Shi-Bao Zhang

The genus Dendrobium (Orchidaceae) is highly renowned for its great medicinal and ornamental values. However, due to morphological similarities among closely related taxa within this genus, certain species are frequently subject to misidentification...

  • Article
  • Open Access
2,195 Views
20 Pages

A New Method for Preparation of Decellularized Human Scaffolds for Facial Reconstruction

  • Elise Lupon,
  • Aylin Acun,
  • Alec R. Andrews,
  • Ruben Oganesyan,
  • Hyshem H. Lancia,
  • Laurent Lantieri,
  • Mark A. Randolph,
  • Curtis L. Cetrulo,
  • Alexandre G. Lellouch and
  • Basak E. Uygun

Vascularized composite allotransplantation (VCA) has emerged as a robust alternative for addressing anatomically complex defects but requires a toxic lifelong immunosuppressive regimen. Tissue engineering offers the promise of creating recipient-spec...

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Curr. Issues Mol. Biol. - ISSN 1467-3045