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Current Issues in Molecular Biology, Volume 47, Issue 4

April 2025 - 81 articles

Cover Story: This review provides an in-depth analysis of the mechanisms driving the association between thrombo-inflammatory manifestations and the incidence of RA, the impact of RA treatment on thrombosis prevalence, and potential therapeutic strategies for managing both conditions concurrently. By integrating recent advancements in rheumatoid arthritis (RA) pathophysiology and thrombo-inflammatory research, this paper provides a comprehensive resource on the inflammatory link between RA and thrombosis while discussing and comparing current and emerging treatment approaches. Further investigation into these mechanisms could facilitate the development of targeted therapies that reduce the risk of thrombosis in patients with RA. View this paper
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Articles (81)

  • Article
  • Open Access
744 Views
14 Pages

Enhanced Bioactivity of Fermented Aralia cordata Extract for Glucose and Immune Modulation

  • Heejong Shin,
  • Hwapyung Kim,
  • Gwangpyung Kim,
  • Yikyoung Kim and
  • Boyong Kim

Excessive glucose absorption is a major contributing factor of metabolic disorders that necessitates effective therapeutic strategies. This study investigates the potential of fermented Aralia cordata extract (FACE) in regulating glucose transport an...

  • Article
  • Open Access
747 Views
17 Pages

Nephroprotective Effects of Tanacetum balsamita Extract on Metabolic-Induced Renal Injury (MIRI) in Rats

  • Rumyana Simeonova,
  • Reneta Gevrenova,
  • Lyubomir Marinov,
  • Yonko Savov and
  • Dimitrina Zheleva-Dimitrova

The progression of type 2 diabetes is associated with multiple complications, one of which is diabetic nephropathy (DN). This study aimed at investigating the nephroprotective potential of two doses 150 mg/kg and 300 mg/kg of Tanacetum balsamita leaf...

  • Article
  • Open Access
789 Views
13 Pages

Prostate cancer is one of the world’s leading causes of cancer-related mortalities. There are several diagnostic tools and treatment plans readily available, such as prostate-specific antigen (PSA) tests and androgen deprivation therapy (ADT)....

  • Review
  • Open Access
3 Citations
5,639 Views
48 Pages

The Inflammatory Link of Rheumatoid Arthritis and Thrombosis: Pathogenic Molecular Circuits and Treatment Approaches

  • Theodora Adamantidi,
  • Maria Stavroula Pisioti,
  • Sofia Pitsouni,
  • Chatzikamari Maria,
  • Karamanis Georgios,
  • Vasiliki Dania,
  • Nikolaos Vordos,
  • Xenophon Krokidis and
  • Alexandros Tsoupras

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic inflammation that primarily affects the joints but can also involve extra-articular organs. Its multifactorial etiology remains incompletely understood, necessitating...

  • Review
  • Open Access
1,026 Views
18 Pages

Folliculin-interacting protein 1 (FNIP1) is a key regulator of cellular metabolism and immune homeostasis, integrating nutrient signaling with proteostasis. FNIP1 forms a complex with folliculin (FLCN) to regulate the mechanistic target of rapamycin...

  • Editorial
  • Open Access
828 Views
6 Pages

Despite significant progress in the treatment of cancer patients, modern oncological therapy faces numerous challenges that are primarily related to the lack of response to treatment caused by the resistance of cancer cells to chemotherapeutics [...]

  • Article
  • Open Access
861 Views
21 Pages

In Silico Identification of Potential Antagonists Targeting the HPV16 E2-E1 Interaction: A Step Toward Novel Therapeutics for Cervical Cancer

  • Jesús Alonso Gandara-Mireles,
  • Verónica Loera Castañeda,
  • Julio Cesar Grijalva Ávila,
  • Ignacio Villanueva Fierro,
  • Cynthia Mora Muñoz,
  • Hugo Payan Gándara,
  • Guadalupe Antonio Loera Castañeda,
  • Leslie Patrón Romero and
  • Horacio Almanza Reyes

Human papillomavirus (HPV) infection is the most prevalent sexually transmitted disease, and a primary cause of persistent infection leading to cervical cancer (CC). CC remains one of the most common malignancies among women worldwide, with approxima...

  • Review
  • Open Access
4 Citations
4,343 Views
29 Pages

Recent Advances in Bone Tissue Engineering: Enhancing the Potential of Mesenchymal Stem Cells for Regenerative Therapies

  • Milena Kostadinova,
  • Miryana Raykovska,
  • Radoil Simeonov,
  • Stephan Lolov and
  • Milena Mourdjeva

Bone tissue engineering (BTE) has emerged as a promising strategy for addressing bone defects and disorders that cannot be repaired through traditional methods. This field leverages the potential of various biomaterials, cells, and bioactive factors...

  • Review
  • Open Access
4 Citations
12,952 Views
25 Pages

The Expanding Role of GLP-1 Receptor Agonists: Advancing Clinical Outcomes in Metabolic and Mental Health

  • Mohamad Al Qassab,
  • Mohammad Mneimneh,
  • Ahmad Jradi,
  • Bassem Derbas,
  • Dana Dabboussi,
  • Justine Khoury Baini,
  • Nadia Katrib,
  • Nadim Chaarani,
  • Philippe Attieh and
  • Amjad Kanaan
  • + 3 authors

Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) have emerged as a promising therapeutic option beyond their established role in managing type 2 diabetes mellitus (T2DM) and obesity. Recent research has highlighted their beneficial effects on li...

  • Review
  • Open Access
2 Citations
1,342 Views
18 Pages

FGFRL1 (fibroblast growth factor receptor-like 1) is a newly identified member of the FGFR family. Its extracellular domain resembles the four conventional FGFRs, while its intracellular part lacks the tyrosine kinase domain necessary for FGF-mediate...

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Curr. Issues Mol. Biol. - ISSN 1467-3045