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Current Issues in Molecular Biology, Volume 45, Issue 12

December 2023 - 54 articles

Cover Story: The dysregulation of energetic metabolism is one of the hallmarks of cancer cells. Indeed, the growth of head and neck cancer cells depends heavily on glycolytic activity, which can be considered a potential therapeutic target. Wnt signaling is one of the pathways that undergoes upregulation in HNSCC. We have shown that Wnt signaling inhibitors—PRI-724 and IWP-O1—affect glycolysis by attenuating the expression of key glycolytic genes—phosphofructokinase M, pyruvate kinase M2, and lactate dehydrogenase A, whose expression is increased in head and neck cancers, especially in HPV-positive cases. Thus, we provide evidence that inhibiting glucose metabolism via Wnt signaling inhibitors is a promising action against tongue cancer cells. View this paper
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Articles (54)

  • Article
  • Open Access
2 Citations
2,257 Views
24 Pages

18 December 2023

The non-structural protein 2 (NSP2) is an RNA-binding protein involved in coronavirus genome replication, and it often decreases human immune response to promote viral invasion and development. It is believed that the NSP2 associates itself with poly...

  • Article
  • Open Access
5 Citations
2,506 Views
14 Pages

Water Extract of Portulaca Oleracea Inhibits PEDV Infection-Induced Pyrolysis by Caspase-1/GSDMD

  • Yu Zhang,
  • Yueyue Liu,
  • Shifa Yang,
  • Bin Yin,
  • Zengcheng Zhao,
  • Zhongli Huang,
  • Jiaqiang Wu,
  • Shuqian Lin and
  • Xin Wang

18 December 2023

Porcine epidemic diarrhea virus (PEDV) belongs to the coronavirus family and the coronavirus genus, causing contact enteric infection in pigs. It is one of the most serious diseases that threatens the pig industry. However, there is currently no spec...

  • Article
  • Open Access
6 Citations
2,595 Views
18 Pages

Hydrogen Attenuates Chronic Intermittent Hypoxia-Induced Cardiac Hypertrophy by Regulating Iron Metabolism

  • Jixian Song,
  • Qi Chen,
  • Shan Xu,
  • Yujing Gou,
  • Yajing Guo,
  • Cuiling Jia,
  • Chenbing Zhao,
  • Zhi Zhang,
  • Boliang Li and
  • Yashuo Zhao
  • + 1 author

16 December 2023

The present study aimed to investigate the impact of hydrogen (H2) on chronic intermittent hypoxia (CIH)-induced cardiac hypertrophy in mice by modulating iron metabolism. C57BL/6N mice were randomly allocated into four groups: control (Con), CIH, CI...

  • Article
  • Open Access
6 Citations
3,444 Views
14 Pages

Expression of Human L-Dopa Decarboxylase (DDC) under Conditions of Oxidative Stress

  • Nikolaos S. Lotsios,
  • Nikolaos Arvanitis,
  • Alexandros G. Charonitakis,
  • George Mpekoulis,
  • Efseveia Frakolaki,
  • Niki Vassilaki,
  • Diamantis C. Sideris and
  • Dido Vassilacopoulou

16 December 2023

Oxidative stress is known to influence mRNA levels, translation, and proteolysis. The importance of oxidative stress has been demonstrated in several human diseases, including neurodegenerative disorders. L-Dopa decarboxylase (DDC) is the enzyme that...

  • Article
  • Open Access
6 Citations
4,367 Views
20 Pages

Improvement in Yield of Extracellular Vesicles Derived from Edelweiss Callus Treated with LED Light and Enhancement of Skin Anti-Aging Indicators

  • Mi-Jung Kim,
  • Hoon Ko,
  • Ji-Young Kim,
  • Hye-Jin Kim,
  • Hwi-Yeob Kim,
  • Hang-Eui Cho,
  • Hyun-Dae Cho,
  • Won-Sang Seo and
  • Hee-Cheol Kang

16 December 2023

The process of skin aging is currently recognized as a disease, and extracellular vesicles (EVs) are being used to care for it. While various EVs are present in the market, there is a growing need for research on improving skin conditions through mic...

  • Review
  • Open Access
17 Citations
9,341 Views
28 Pages

Clinical Significance of SOX10 Expression in Human Pathology

  • Hisham F. Bahmad,
  • Aran Thiravialingam,
  • Karthik Sriganeshan,
  • Jeffrey Gonzalez,
  • Veronica Alvarez,
  • Stephanie Ocejo,
  • Alvaro R. Abreu,
  • Rima Avellan,
  • Alejandro H. Arzola and
  • Sana Hachem
  • + 1 author

15 December 2023

The embryonic development of neural crest cells and subsequent tissue differentiation are intricately regulated by specific transcription factors. Among these, SOX10, a member of the SOX gene family, stands out. Located on chromosome 22q13, the SOX10...

  • Communication
  • Open Access
4 Citations
1,869 Views
10 Pages

NRG1 Regulates Proliferation, Migration and Differentiation of Human Limbal Epithelial Stem Cells

  • Bofeng Wang,
  • Huizhen Guo,
  • Zhuo Han,
  • Siqi Wu,
  • Jiafeng Liu,
  • Zesong Lin,
  • Fengjiao An,
  • Jin Zhu and
  • Mingsen Li

14 December 2023

Limbal epithelial stem/progenitor cells (LESCs) proliferate, migrate and differentiate into mature corneal epithelium cells (CECs) that cover the ocular surface. LESCs play a crucial role in the maintenance and regeneration of the corneal epithelium,...

  • Article
  • Open Access
1 Citations
2,165 Views
12 Pages

The Cytotoxicity of Cotyledon orbiculata Aqueous Extract and the Biogenic Silver Nanoparticles Derived from the Extract

  • Caroline Tyavambiza,
  • Mervin Meyer,
  • Adedoja Dorcas Wusu,
  • Abram Madiehe and
  • Samantha Meyer

14 December 2023

Green synthesized silver nanoparticles (AgNPs) have become popular because of their promising biological activities. However, for most of these nanoparticles, the cytotoxic effects have not been determined and their safety is not guaranteed. In a pre...

  • Article
  • Open Access
3 Citations
2,006 Views
12 Pages

14 December 2023

Immune-modulatory effects in obese-diabetes (db/db) mice were observed to understand the possible mechanism(s) of ephedrine-induced unfavorable responses. The ephedrine doses were selected based on the FDA report (NTP Tech Rep Ser NO 307; CAS# 134-72...

  • Article
  • Open Access
3 Citations
1,967 Views
18 Pages

13 December 2023

The development of a shell is a complex calcium metabolic process involving shell matrix proteins (SMPs). In this study, we describe the isolation, characterization, and expression of SMP5 and investigate its potential regulatory role in the shell bi...

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Curr. Issues Mol. Biol. - ISSN 1467-3045Creative Common CC BY license