Next Article in Journal
Anti-Inflammatory Drug Design Using a Molecular Hybridization Approach
Next Article in Special Issue
Anti-HCV RNA Aptamers Targeting the Genomic cis-Acting Replication Element
Previous Article in Journal
Effects of the Ethyl Acetate Fraction of Alchornea triplinervia on Healing Gastric Ulcer in Rats
Previous Article in Special Issue
Methods To Identify Aptamers against Cell Surface Biomarkers
Open AccessReview

Coupling Aptamers to Short Interfering RNAs as Therapeutics

Istituto per l’Endocrinologia e l’Oncologia Sperimentale del CNR “G. Salvatore”, Via S. Pansini 5, 80131 Naples, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli “Federico II”, Via S. Pansini 5, 80131 Naples, Italy
Author to whom correspondence should be addressed.
Pharmaceuticals 2011, 4(11), 1434-1449;
Received: 22 September 2011 / Revised: 13 October 2011 / Accepted: 24 October 2011 / Published: 27 October 2011
(This article belongs to the Special Issue Aptamer-Based Therapeutics)
RNA-based approaches are among the most promising strategies aimed at developing safer and more effective therapeutics. RNA therapeutics include small non-coding miRNAs, small interfering RNA, RNA aptamers and more recently, small activating RNAs. However, major barriers exist to the use of RNAs as therapeutics such as resistance to nucleases present in biological fluids, poor chemical stability, need of specific cell targeted delivery and easy entry into the cell. Such issues have been addressed by several recent reports that show the possibility of introducing chemical modifications in small RNAs to stabilize the molecular conformation and increase by several fold their integrity, while still preserving the functional activity. Further, several aptamers have been developed as excellent candidates for the specific recognition of cell surface targets. In the last few years, by taking advantage of recent advances in the small RNA field, molecular bioconjugates have been designed that permit specific targeting and may act as cargoes for cell internalization of small RNAs acting on gene expression that will be discussed in this review. View Full-Text
Keywords: aptamer; intracellular delivery; microRNA; small interfering RNA aptamer; intracellular delivery; microRNA; small interfering RNA
MDPI and ACS Style

Cerchia, L.; Esposito, C.L.; Camorani, S.; Catuogno, S.; Franciscis, V. Coupling Aptamers to Short Interfering RNAs as Therapeutics. Pharmaceuticals 2011, 4, 1434-1449.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Back to TopTop