Sensors, Volume 19, Issue 11
June-1 2019 - 226 articles
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Cover Story: Non-specific adsorption (NSA) is a persistent problem that negatively affects all biosensors, causing decreases in sensitivity, specificity, and reproducibility. Both passive and active removal methods exist to remedy this issue, for example, by coating the surface or generating surface forces to shear away weakly adhered biomolecules, respectively. However, many surface coatings are not compatible or effective for sensing and, thus, active removal methods have been developed to combat this phenomenon. This review aims to provide an overview of methods of NSA reduction in biosensing, focusing on the shift from passive methods to active methods in the past decade. Attention is focused on protein NSA, due to their common use in biosensing for biomarker diagnostics. To our best knowledge, this is the first review to comprehensively discuss active NSA removal methods. View this paper. 
