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Open AccessArticle

Gold Nanocage-Based Electrochemical Sensing Platform for Sensitive Detection of Luteolin

1
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China
2
Key Laboratory of Sensor Analysis of Tumor Marker of Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China
3
Key Laboratory of Medicinal and Edible Plants Resources of Hainan Province, School of Chemical and Material Engineering, Hainan Institute of Science and Technology, Haikou 571126, China
*
Author to whom correspondence should be addressed.
Sensors 2018, 18(7), 2309; https://doi.org/10.3390/s18072309
Received: 2 June 2018 / Revised: 7 July 2018 / Accepted: 7 July 2018 / Published: 17 July 2018
(This article belongs to the Section Chemical Sensors)
A simple and sensitive electrochemical sensor was developed for the detection of tracelevels of luteolin. The sensoris based on a novel type of chemically modified electrode: gold nanocage (AuNCs)-modified carbon ionic liquid electrode (CILE). To construct this electrochemical sensing platform for luteolin, CILE is initially prepared by using 1-hexylpyridinium hexafluorophosphate as the binder and then AuNCs are coated on the surface of CILE to fabricate AuNCs-modified CILE (AuNCs/CILE). Electrochemical studies have shown that AuNCs/CILE can exhibit enhanced electrocatalytic activity toward the redox reaction of luteolin, therefore, the redox peak current of luteolin can be greatly improved, resulting in the high sensitivity of the developed sensor. Under the optimal conditions, the oxidation peak currents of the sensor increase linearly with an increase in the luteolin concentration in a range from 1 to 1000 nM with a detection limit of 0.4 nM, which is lower than those of most reported electrochemical luteolin sensors. Moreover, the reproducibility, precision, selectivity, and stability of this sensor are excellent. Finally, the sensing system was applied to the analysis of luteolin-spiked drug samples and the recovery in all cases was 95.0–96.7%, indicating the potential application of this simple, facile, and sensitive sensing system in pharmaceutical analysis. View Full-Text
Keywords: luteolin; gold nanocages; carbon ionic liquid electrode; electrochemistry luteolin; gold nanocages; carbon ionic liquid electrode; electrochemistry
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MDPI and ACS Style

Li, X.; Zou, R.; Niu, Y.; Sun, W.; Shao, T.; Chen, X. Gold Nanocage-Based Electrochemical Sensing Platform for Sensitive Detection of Luteolin. Sensors 2018, 18, 2309.

AMA Style

Li X, Zou R, Niu Y, Sun W, Shao T, Chen X. Gold Nanocage-Based Electrochemical Sensing Platform for Sensitive Detection of Luteolin. Sensors. 2018; 18(7):2309.

Chicago/Turabian Style

Li, Xiaobao; Zou, Ruyi; Niu, Yanyan; Sun, Wei; Shao, Taiming; Chen, Xiaoqin. 2018. "Gold Nanocage-Based Electrochemical Sensing Platform for Sensitive Detection of Luteolin" Sensors 18, no. 7: 2309.

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