On-Chip Magnetic Bead Manipulation and Detection Using a Magnetoresistive Sensor-Based Micro-Chip: Design Considerations and Experimental Characterization
Abstract
:1. Introduction
2. Theoretical Basis
3. Materials and Methods
3.1. Fabrication of the Magnetic Actuator
3.2. Sample Preparation and Experimental Setup for SPB Manipulation
3.3. TMR Sensor Integration and Experimental Setup for Magnetic Bead Detection
4. Results
4.1. Numerical Results
4.2. Experimental Results
5. Discussion
6. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
Appendix A
Material | Thermal Conductivity (W/m·K) | Density | Material | Thermal conductivity (W/m·K) |
---|---|---|---|---|
Water | 130 | 2329 | 700 | - |
Silicon | 0.58 | 1000 | 4183 | - |
Gold | 317 | 19300 | 129 | Q × t |
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Bead Type | Radius (m) × 10−6 | Volume (m3) × 10−16 | Density (g/m3) × 106 | Mass (g) × 10−10 | Magnetic Content (%) | Mass of Magnetic Content (g) × 10−12 | Volume of Magnetic Content (m3) × 10−18 | Volume Susceptibility |
---|---|---|---|---|---|---|---|---|
COMPELTM | 3.1 | 1.2479 | 1.1 | 1.3727 | 5.5 | 7.5499 | 1.4519 | 0.26 |
Dynabead® | 1.4 | 0.11494 | 1.6 | 0.1839 | 14 | 2.5746 | 0.49512 | 0.84 |
Bead Type | Method | 5 μm | 10 μm | 15 μm | 20 μm |
---|---|---|---|---|---|
COMPEL™ | Dipole approximation | 0.9 s | 7.47 | 30.59 | 101.7 |
Volume integration | 3.9 | 18.7 | 60.6 | 164.8 | |
Dynabead® | Dipole approximation | 0.36 | 3.06 | 12.54 | 41.7 |
Volume integration | 0.75 | 4.72 | 17.3 | 55.79 |
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Gooneratne, C.P.; Kodzius, R.; Li, F.; Foulds, I.G.; Kosel, J. On-Chip Magnetic Bead Manipulation and Detection Using a Magnetoresistive Sensor-Based Micro-Chip: Design Considerations and Experimental Characterization. Sensors 2016, 16, 1369. https://doi.org/10.3390/s16091369
Gooneratne CP, Kodzius R, Li F, Foulds IG, Kosel J. On-Chip Magnetic Bead Manipulation and Detection Using a Magnetoresistive Sensor-Based Micro-Chip: Design Considerations and Experimental Characterization. Sensors. 2016; 16(9):1369. https://doi.org/10.3390/s16091369
Chicago/Turabian StyleGooneratne, Chinthaka P., Rimantas Kodzius, Fuquan Li, Ian G. Foulds, and Jürgen Kosel. 2016. "On-Chip Magnetic Bead Manipulation and Detection Using a Magnetoresistive Sensor-Based Micro-Chip: Design Considerations and Experimental Characterization" Sensors 16, no. 9: 1369. https://doi.org/10.3390/s16091369