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Communication

Regioselective Synthesis of 4-Bromo-3-formyl-N-phenyl-5-propylthiophene-2-carboxamide

1
Department of Chemistry, Indian Institute Technology Kharagpur, Kharagpur 721302, India
2
Department of Structural Biology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Fawaz Aldabbagh
Molbank 2021, 2021(4), M1296; https://doi.org/10.3390/M1296
Received: 4 November 2021 / Revised: 9 November 2021 / Accepted: 9 November 2021 / Published: 16 November 2021
(This article belongs to the Collection Heterocycle Reactions)
We synthesized 4-bromo-3-formyl-N-phenyl-5-propylthiophene-2-carboxamide by using three successive direct lithiations and a bromination reaction starting from thiophene. All these lithiation reactions were carried out at −78 °C to RT over a period of 1 to 24 h based on the reactivity of electrophile. This is a four-step protocol starting from thiophene with an overall yield of 47%. View Full-Text
Keywords: thiophene; regioselective; n-BuLi; lithiation thiophene; regioselective; n-BuLi; lithiation
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MDPI and ACS Style

Bar, S.; Martin, M.I. Regioselective Synthesis of 4-Bromo-3-formyl-N-phenyl-5-propylthiophene-2-carboxamide. Molbank 2021, 2021, M1296. https://doi.org/10.3390/M1296

AMA Style

Bar S, Martin MI. Regioselective Synthesis of 4-Bromo-3-formyl-N-phenyl-5-propylthiophene-2-carboxamide. Molbank. 2021; 2021(4):M1296. https://doi.org/10.3390/M1296

Chicago/Turabian Style

Bar, Sukanta, and Maxwell I. Martin 2021. "Regioselective Synthesis of 4-Bromo-3-formyl-N-phenyl-5-propylthiophene-2-carboxamide" Molbank 2021, no. 4: M1296. https://doi.org/10.3390/M1296

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