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Regioselective Synthesis of 4-Bromo-3-formyl-N-phenyl-5-propylthiophene-2-carboxamide

Department of Chemistry, Indian Institute Technology Kharagpur, Kharagpur 721302, India
Department of Structural Biology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA
Author to whom correspondence should be addressed.
Academic Editor: Fawaz Aldabbagh
Molbank 2021, 2021(4), M1296;
Received: 4 November 2021 / Revised: 9 November 2021 / Accepted: 9 November 2021 / Published: 16 November 2021
(This article belongs to the Collection Heterocycle Reactions)
We synthesized 4-bromo-3-formyl-N-phenyl-5-propylthiophene-2-carboxamide by using three successive direct lithiations and a bromination reaction starting from thiophene. All these lithiation reactions were carried out at −78 °C to RT over a period of 1 to 24 h based on the reactivity of electrophile. This is a four-step protocol starting from thiophene with an overall yield of 47%. View Full-Text
Keywords: thiophene; regioselective; n-BuLi; lithiation thiophene; regioselective; n-BuLi; lithiation
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MDPI and ACS Style

Bar, S.; Martin, M.I. Regioselective Synthesis of 4-Bromo-3-formyl-N-phenyl-5-propylthiophene-2-carboxamide. Molbank 2021, 2021, M1296.

AMA Style

Bar S, Martin MI. Regioselective Synthesis of 4-Bromo-3-formyl-N-phenyl-5-propylthiophene-2-carboxamide. Molbank. 2021; 2021(4):M1296.

Chicago/Turabian Style

Bar, Sukanta, and Maxwell I. Martin 2021. "Regioselective Synthesis of 4-Bromo-3-formyl-N-phenyl-5-propylthiophene-2-carboxamide" Molbank 2021, no. 4: M1296.

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