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Propyl Gallate

Department of Pharmaceutical Industry, Hanoi University of Pharmacy, Hanoi 110403, Vietnam
Department of Traditional Pharmacy, Hanoi University of Pharmacy, Hanoi 110403, Vietnam
Laboratory for Establishment of Reference Standards, National Institute of Drug Quality Control, Hanoi 11022, Vietnam
School of Environmental and Life Sciences, College of Engineering, Science and Environment, University of Newcastle, NSW 2308, Australia
Author to whom correspondence should be addressed.
Academic Editor: Norbert Haider
Molbank 2021, 2021(2), M1201;
Received: 29 March 2021 / Revised: 9 April 2021 / Accepted: 9 April 2021 / Published: 12 April 2021
(This article belongs to the Section Organic Synthesis)
The title compound, propyl gallate (III), is an important substance popularly used in the food, cosmetic and pharmaceutical industries. Current chemical syntheses of this compound are based on the acylation supported by thionyl chloride, DIC/DMAP or Fischer esterification using a range of homogenous and heterogenous catalysts. In this paper, an efficient, green, straightforward, and economical method for synthesizing propyl gallate using potassium hydrogen sulfate, KHSO4, as the heterogenous acidic catalyst has been developed for the first time. In addition, this paper provides a comprehensive spectral dataset for the title compound, especially the new data on DEPT and 2D NMR (HSQC and HMBC) spectra which are not currently available in the literature. View Full-Text
Keywords: antioxidant; esterification; potassium hydrogen sulfate; propyl gallate antioxidant; esterification; potassium hydrogen sulfate; propyl gallate
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MDPI and ACS Style

Nguyen, V.H.; Le, M.N.; Nguyen, H.B.; Ha, K.O.; Pham, T.H.V.; Nguyen, T.H.; Dao, N.S.H.; Nguyen, V.G.; Nguyen, D.L.; Trinh, N.T. Propyl Gallate. Molbank 2021, 2021, M1201.

AMA Style

Nguyen VH, Le MN, Nguyen HB, Ha KO, Pham THV, Nguyen TH, Dao NSH, Nguyen VG, Nguyen DL, Trinh NT. Propyl Gallate. Molbank. 2021; 2021(2):M1201.

Chicago/Turabian Style

Nguyen, Van H.; Le, Minh N.; Nguyen, Hoa B.; Ha, Kieu O.; Pham, Thai H.V.; Nguyen, Thi H.; Dao, Nguyet S.H.; Nguyen, Van G.; Nguyen, Dinh L.; Trinh, Nguyen T. 2021. "Propyl Gallate" Molbank 2021, no. 2: M1201.

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