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Article

Age-Related Alterations in the Level and Metabolism of Serotonin in the Brain of Males and Females of Annual Turquoise Killifish (Nothobranchius furzeri)

by
Valentina S. Evsiukova
1,
Alla B. Arefieva
2,
Ivan E. Sorokin
3 and
Alexander V. Kulikov
2,*
1
Department of Psychoneuropharmacology, Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia
2
Department of Genetic Collections of Neural Disorders, Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia
3
Department of Monogenic Forms of Human Common Disorders, Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(4), 3185; https://doi.org/10.3390/ijms24043185
Submission received: 17 November 2022 / Revised: 3 February 2023 / Accepted: 3 February 2023 / Published: 6 February 2023
(This article belongs to the Special Issue Aquatic Organisms as Disease Models)
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Abstract

The annual turquoise killifish (Nothobranchius furzeri) is a laboratory model organism for neuroscience of aging. In the present study, we investigated for the first time the levels of serotonin and its main metabolite, 5-hydroxyindoleacetic acid, as well as the activities of the key enzymes of its synthesis, tryptophan hydroxylases, and degradation, monoamine oxidase, in the brains of 2-, 4- and 7-month-old male and female N. furzeri. The marked effect of age on the body mass and the level of serotonin, as well as the activities of tryptophan hydroxylases and monoamine oxidase in the brain of killifish were revealed. The level of serotonin decreased in the brain of 7-month-old males and females compared with 2-month-old ones. A significant decrease in the tryptophan hydroxylase activity and an increase in the monoamine oxidase activity in the brain of 7-month-old females compared to 2-month-old females was shown. These findings agree with the age-related alterations in expression of the genes encoding tryptophan hydroxylases and monoamine oxidase. N. furzeri is a suitable model with which to study the fundamental problems of age-related changes of the serotonin system in the brain.
Keywords: turquoise killifish; aging; serotonin; tryptophan hydroxylase; monoamine oxidase; brain turquoise killifish; aging; serotonin; tryptophan hydroxylase; monoamine oxidase; brain

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MDPI and ACS Style

Evsiukova, V.S.; Arefieva, A.B.; Sorokin, I.E.; Kulikov, A.V. Age-Related Alterations in the Level and Metabolism of Serotonin in the Brain of Males and Females of Annual Turquoise Killifish (Nothobranchius furzeri). Int. J. Mol. Sci. 2023, 24, 3185. https://doi.org/10.3390/ijms24043185

AMA Style

Evsiukova VS, Arefieva AB, Sorokin IE, Kulikov AV. Age-Related Alterations in the Level and Metabolism of Serotonin in the Brain of Males and Females of Annual Turquoise Killifish (Nothobranchius furzeri). International Journal of Molecular Sciences. 2023; 24(4):3185. https://doi.org/10.3390/ijms24043185

Chicago/Turabian Style

Evsiukova, Valentina S., Alla B. Arefieva, Ivan E. Sorokin, and Alexander V. Kulikov. 2023. "Age-Related Alterations in the Level and Metabolism of Serotonin in the Brain of Males and Females of Annual Turquoise Killifish (Nothobranchius furzeri)" International Journal of Molecular Sciences 24, no. 4: 3185. https://doi.org/10.3390/ijms24043185

APA Style

Evsiukova, V. S., Arefieva, A. B., Sorokin, I. E., & Kulikov, A. V. (2023). Age-Related Alterations in the Level and Metabolism of Serotonin in the Brain of Males and Females of Annual Turquoise Killifish (Nothobranchius furzeri). International Journal of Molecular Sciences, 24(4), 3185. https://doi.org/10.3390/ijms24043185

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