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Article

Verrucosidin Derivatives from the Deep Sea Cold-Seep-Derived Fungus Penicillium polonicum CS-252

by
Yanhe Li
1,2,3,
Xiaoming Li
1,2,
Xin Li
1,2,
Suiqun Yang
1,2,
Bingui Wang
1,2,3,4,* and
Honglei Li
1,2,*
1
CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China
2
Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Wenhai Road 1, Qingdao 266237, China
3
College of Marine Science, University of Chinese Academy of Sciences, Yuquan Road 19A, Beijing 100049, China
4
Center for Ocean Mega-Science, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2022, 23(10), 5567; https://doi.org/10.3390/ijms23105567
Submission received: 9 April 2022 / Revised: 1 May 2022 / Accepted: 5 May 2022 / Published: 16 May 2022
(This article belongs to the Special Issue Marine Natural Products Identified by Molecular Approaches and Human Disease)
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Abstract

Six novel verrucosidin derivatives, namely, poloncosidins A–F (1–6), together with one known analogue (7), were isolated and identified from the deep-sea-derived fungus Penicillium polonicum CS-252, which was obtained from cold-seep sediments collected in the South China Sea at a depth of 1183 m. Their structures were mainly established on the basis of a detailed interpretation of NMR spectroscopic and mass spectrometric data. The relative and absolute configurations of compounds 1–6 were determined by ECD calculations and a DP4+ probability analysis. Compounds 1–5 represent the first examples of verrucosidins with a 2,5-dihydrofuran ring which is uncommon among the known analogues. These compounds exhibited inhibitory activities against several human and aquatic pathogens with MIC values ranging from 4 to 32 μg/mL.
Keywords: deep-sea-derived fungus; Penicillium polonicum; verrucosidin derivatives; structure elucidation; antimicrobial activity deep-sea-derived fungus; Penicillium polonicum; verrucosidin derivatives; structure elucidation; antimicrobial activity

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MDPI and ACS Style

Li, Y.; Li, X.; Li, X.; Yang, S.; Wang, B.; Li, H. Verrucosidin Derivatives from the Deep Sea Cold-Seep-Derived Fungus Penicillium polonicum CS-252. Int. J. Mol. Sci. 2022, 23, 5567. https://doi.org/10.3390/ijms23105567

AMA Style

Li Y, Li X, Li X, Yang S, Wang B, Li H. Verrucosidin Derivatives from the Deep Sea Cold-Seep-Derived Fungus Penicillium polonicum CS-252. International Journal of Molecular Sciences. 2022; 23(10):5567. https://doi.org/10.3390/ijms23105567

Chicago/Turabian Style

Li, Yanhe, Xiaoming Li, Xin Li, Suiqun Yang, Bingui Wang, and Honglei Li. 2022. "Verrucosidin Derivatives from the Deep Sea Cold-Seep-Derived Fungus Penicillium polonicum CS-252" International Journal of Molecular Sciences 23, no. 10: 5567. https://doi.org/10.3390/ijms23105567

APA Style

Li, Y., Li, X., Li, X., Yang, S., Wang, B., & Li, H. (2022). Verrucosidin Derivatives from the Deep Sea Cold-Seep-Derived Fungus Penicillium polonicum CS-252. International Journal of Molecular Sciences, 23(10), 5567. https://doi.org/10.3390/ijms23105567

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