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Review

Oxidative Stress and NADPH Oxidase: Connecting Electromagnetic Fields, Cation Channels and Biological Effects

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Department of Biology, Section of Genetics, Cell & Developmental Biology, University of Patras, 10679 Patras, Greece
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Section of Cell Biology and Biophysics, Department of Biology, National and Kapodistrian University of Athens, 26504 Athens, Greece
*
Author to whom correspondence should be addressed.
Academic Editors: Nino Russo and Akihiko Nunomura
Int. J. Mol. Sci. 2021, 22(18), 10041; https://doi.org/10.3390/ijms221810041
Received: 10 July 2021 / Revised: 1 September 2021 / Accepted: 15 September 2021 / Published: 17 September 2021
(This article belongs to the Special Issue Biological Effects of Non-ionizing Radiation)
Electromagnetic fields (EMFs) disrupt the electrochemical balance of biological membranes, thereby causing abnormal cation movement and deterioration of the function of membrane voltage-gated ion channels. These can trigger an increase of oxidative stress (OS) and the impairment of all cellular functions, including DNA damage and subsequent carcinogenesis. In this review we focus on the main mechanisms of OS generation by EMF-sensitized NADPH oxidase (NOX), the involved OS biochemistry, and the associated key biological effects. View Full-Text
Keywords: EMF; voltage-gated calcium channels; cation channels; ROS; DNA damage; carcinogenesis EMF; voltage-gated calcium channels; cation channels; ROS; DNA damage; carcinogenesis
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MDPI and ACS Style

Georgiou, C.D.; Margaritis, L.H. Oxidative Stress and NADPH Oxidase: Connecting Electromagnetic Fields, Cation Channels and Biological Effects. Int. J. Mol. Sci. 2021, 22, 10041. https://doi.org/10.3390/ijms221810041

AMA Style

Georgiou CD, Margaritis LH. Oxidative Stress and NADPH Oxidase: Connecting Electromagnetic Fields, Cation Channels and Biological Effects. International Journal of Molecular Sciences. 2021; 22(18):10041. https://doi.org/10.3390/ijms221810041

Chicago/Turabian Style

Georgiou, Christos D., and Lukas H. Margaritis 2021. "Oxidative Stress and NADPH Oxidase: Connecting Electromagnetic Fields, Cation Channels and Biological Effects" International Journal of Molecular Sciences 22, no. 18: 10041. https://doi.org/10.3390/ijms221810041

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