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Review

Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review

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Department of Food Chemistry, Technology and Biotechnology, Gdańsk University of Technology, 11/12 Narutowicza St., 80-233 Gdańsk, Poland
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Department of Bromatology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia
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Department of Nutrition and Natural Products, Migal-Galilee Research Institute, Kiryat Shmona 11016, Israel
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Department of Nutritional Sciences, Tel-Hai College, Qiryat Shemona 1220800, Israel
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Mutagenesis Unit, Institute for Medical Research and Occupational Health, 10000 Zagreb, Croatia
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Research Group on Community Nutrition & Oxidative Stress, University of Balearic Islands—IUNICS, IDISBA & CIBEROBN (Physiopathology of Obesity and Nutrition), 07122 Palma de Mallorca, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Anindita Das
Int. J. Mol. Sci. 2021, 22(18), 10037; https://doi.org/10.3390/ijms221810037
Received: 19 August 2021 / Revised: 14 September 2021 / Accepted: 15 September 2021 / Published: 17 September 2021
Cardiotoxicity is a frequent undesirable phenomenon observed during oncological treatment that limits the therapeutic dose of antitumor drugs and thus may decrease the effectiveness of cancer eradication. Almost all antitumor drugs exhibit toxic properties towards cardiac muscle. One of the underlying causes of cardiotoxicity is the stimulation of oxidative stress by chemotherapy. This suggests that an appropriately designed diet or dietary supplements based on edible plants rich in antioxidants could decrease the toxicity of antitumor drugs and diminish the risk of cardiac failure. This comprehensive review compares the cardioprotective efficacy of edible plant extracts and foodborne phytochemicals whose beneficial activity was demonstrated in various models in vivo and in vitro. The studies selected for this review concentrated on a therapy frequently applied in cancer, anthracycline antibiotic—doxorubicin—as the oxidative stress- and cardiotoxicity-inducing agent. View Full-Text
Keywords: cardiotoxicity; cardioprotectants; phytochemicals; antioxidants; anthracyclines cardiotoxicity; cardioprotectants; phytochemicals; antioxidants; anthracyclines
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MDPI and ACS Style

Koss-Mikołajczyk, I.; Todorovic, V.; Sobajic, S.; Mahajna, J.; Gerić, M.; Tur, J.A.; Bartoszek, A. Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review. Int. J. Mol. Sci. 2021, 22, 10037. https://doi.org/10.3390/ijms221810037

AMA Style

Koss-Mikołajczyk I, Todorovic V, Sobajic S, Mahajna J, Gerić M, Tur JA, Bartoszek A. Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review. International Journal of Molecular Sciences. 2021; 22(18):10037. https://doi.org/10.3390/ijms221810037

Chicago/Turabian Style

Koss-Mikołajczyk, Izabela, Vanja Todorovic, Sladjana Sobajic, Jamal Mahajna, Marko Gerić, Josep A. Tur, and Agnieszka Bartoszek. 2021. "Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review" International Journal of Molecular Sciences 22, no. 18: 10037. https://doi.org/10.3390/ijms221810037

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