New Structural Perspectives in G Protein-Coupled Receptor-Mediated Src Family Kinase Activation
Abstract
:1. Introduction
2. Structural Hallmarks of SFKs
3. Modes of SFK Activation
4. Src Activation through a GPCR–Arrestin Complex
5. Src Activation by G Proteins
6. Src Family Kinases as Direct Effectors of GPCRs
7. GPCR-Mediated Src Signaling with Undefined Mediators
Funding
Conflicts of Interest
References
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GPCR | G-Protein | Arrestin | Direct | Other | References |
---|---|---|---|---|---|
α2AR | Arrestin-2/3 | [42] | |||
β2AR | Arrestin-2 | [43,44] | |||
β3AR | 3rd ICL | [44] | |||
D1R | Arresin-3 | unknown | [45,46] | ||
D2R | Arrestin-2 | unknown | [47,48] | ||
D4R | 3rd ICL | [49] | |||
V1bR | unknown | [50] | |||
V2R | Indication of direct | [50] | |||
GnRH-a | Indication of Gβγ protein | [51,52] | |||
M1R | Indication of Gαq protein | [53] | |||
M2R | Arrestin-2 | [43,54] | |||
M3R | Arrestin | [55] | |||
M4R | unknown | [54] | |||
B1R | Gαi | unknown | [56,57] | ||
ETAR | unknown | [58] | |||
ATR2 | unknown | [59,60] | |||
Latrophilin-2 | unknown | [61] | |||
GPR56 (ADGRG1) | unknown | [62] |
3ICL | C-Terminus | Predicted SFK SH3 Domain Interactions | |
---|---|---|---|
b1AR | REAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALRE | CRSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV | FGR, LYN |
b2AR | RVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKT | PDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL | - |
b3AR | RVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALC | RSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS | SRC, FGR, LYN, HCK, LCK, FYN |
P2Y2 | MARRLLKPAYGTSGGLPRAKRKSVRT | GQRLVRFARDAKPPTGPSPATPARRRLGLRRSDRTDMQRIEDVLGSSEDSRRTESTPAGSENTKDIRL | FGR |
5HT6 | CRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALK | PLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN | LYN |
D1R | RIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLK | RKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT | - |
D2R | IVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQ | EFRKAFLKILHC | - |
D3R | RIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQ | NIEFRKAFLKILSC | LYN |
D4R | ATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMR | NAEFRNVFRKALRACC | SRC, FGR, HCK, LYN, |
D5R | RIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLK | FNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH | - |
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Berndt, S.; Liebscher, I. New Structural Perspectives in G Protein-Coupled Receptor-Mediated Src Family Kinase Activation. Int. J. Mol. Sci. 2021, 22, 6489. https://doi.org/10.3390/ijms22126489
Berndt S, Liebscher I. New Structural Perspectives in G Protein-Coupled Receptor-Mediated Src Family Kinase Activation. International Journal of Molecular Sciences. 2021; 22(12):6489. https://doi.org/10.3390/ijms22126489
Chicago/Turabian StyleBerndt, Sandra, and Ines Liebscher. 2021. "New Structural Perspectives in G Protein-Coupled Receptor-Mediated Src Family Kinase Activation" International Journal of Molecular Sciences 22, no. 12: 6489. https://doi.org/10.3390/ijms22126489