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Article

Engineering of Janus-Like Dendrimers with Peptides Derived from Glycoproteins of Herpes Simplex Virus Type 1: Toward a Versatile and Novel Antiviral Platform

1
Department of Agricultural Sciences, University of Naples “Federico II”, Via Università 100, Portici, 80055 Naples, Italy
2
Department of Pharmacy and CIRPEB, University of Naples “Federico II”, Via Montesano 49, 80131 Naples, Italy
3
Department of Chemistry and Molecular Design Institute, New York University, New York, NY 10003, USA
4
Department of Experimental Medicine, Second University of Naples, Via de Crecchio 7, 80138 Naples, Italy
5
Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Istvan Simon
Int. J. Mol. Sci. 2021, 22(12), 6488; https://doi.org/10.3390/ijms22126488
Received: 25 May 2021 / Revised: 9 June 2021 / Accepted: 11 June 2021 / Published: 17 June 2021
(This article belongs to the Collection Feature Papers in Molecular Biophysics)
Novel antiviral nanotherapeutics, which may inactivate the virus and block it from entering host cells, represent an important challenge to face viral global health emergencies around the world. Using a combination of bioorthogonal copper-catalyzed 1,3-dipolar alkyne/azide cycloaddition (CuAAC) and photoinitiated thiol–ene coupling, monofunctional and bifunctional peptidodendrimer conjugates were obtained. The conjugates are biocompatible and demonstrate no toxicity to cells at biologically relevant concentrations. Furthermore, the orthogonal addition of multiple copies of two different antiviral peptides on the surface of a single dendrimer allowed the resulting bioconjugates to inhibit Herpes simplex virus type 1 at both the early and the late stages of the infection process. The presented work builds on further improving this attractive design to obtain a new class of therapeutics. View Full-Text
Keywords: antiviral compounds; dendrimers; peptides antiviral compounds; dendrimers; peptides
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MDPI and ACS Style

Falanga, A.; Del Genio, V.; Kaufman, E.A.; Zannella, C.; Franci, G.; Weck, M.; Galdiero, S. Engineering of Janus-Like Dendrimers with Peptides Derived from Glycoproteins of Herpes Simplex Virus Type 1: Toward a Versatile and Novel Antiviral Platform. Int. J. Mol. Sci. 2021, 22, 6488. https://doi.org/10.3390/ijms22126488

AMA Style

Falanga A, Del Genio V, Kaufman EA, Zannella C, Franci G, Weck M, Galdiero S. Engineering of Janus-Like Dendrimers with Peptides Derived from Glycoproteins of Herpes Simplex Virus Type 1: Toward a Versatile and Novel Antiviral Platform. International Journal of Molecular Sciences. 2021; 22(12):6488. https://doi.org/10.3390/ijms22126488

Chicago/Turabian Style

Falanga, Annarita, Valentina Del Genio, Elizabeth A. Kaufman, Carla Zannella, Gianluigi Franci, Marcus Weck, and Stefania Galdiero. 2021. "Engineering of Janus-Like Dendrimers with Peptides Derived from Glycoproteins of Herpes Simplex Virus Type 1: Toward a Versatile and Novel Antiviral Platform" International Journal of Molecular Sciences 22, no. 12: 6488. https://doi.org/10.3390/ijms22126488

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