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Review

Roles of Nuclear Receptors in Vascular Calcification

1
Université Côte d’Azur, CHU, INSERM, C3M, 06204 Nice, France
2
Université Côte d’Azur, INSERM, C3M, 06204 Nice, France
*
Author to whom correspondence should be addressed.
Academic Editor: Anastasios Lymperopoulos
Int. J. Mol. Sci. 2021, 22(12), 6491; https://doi.org/10.3390/ijms22126491
Received: 18 May 2021 / Revised: 10 June 2021 / Accepted: 14 June 2021 / Published: 17 June 2021
(This article belongs to the Special Issue Nuclear Receptors and Cardiovascular Disease)
Vascular calcification is defined as an inappropriate accumulation of calcium depots occurring in soft tissues, including the vascular wall. Growing evidence suggests that vascular calcification is an actively regulated process, sharing similar mechanisms with bone formation, implicating both inhibitory and inducible factors, mediated by osteoclast-like and osteoblast-like cells, respectively. This process, which occurs in nearly all the arterial beds and in both the medial and intimal layers, mainly involves vascular smooth muscle cells. In the vascular wall, calcification can have different clinical consequences, depending on the pattern, localization and nature of calcium deposition. Nuclear receptors are transcription factors widely expressed, activated by specific ligands that control the expression of target genes involved in a multitude of pathophysiological processes, including metabolism, cancer, inflammation and cell differentiation. Some of them act as drug targets. In this review we describe and discuss the role of different nuclear receptors in the control of vascular calcification. View Full-Text
Keywords: transcription factors; gene regulation; mineralization; calcium; extracellular matrix; arterial wall; vascular cells transcription factors; gene regulation; mineralization; calcium; extracellular matrix; arterial wall; vascular cells
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MDPI and ACS Style

Chinetti, G.; Neels, J.G. Roles of Nuclear Receptors in Vascular Calcification. Int. J. Mol. Sci. 2021, 22, 6491. https://doi.org/10.3390/ijms22126491

AMA Style

Chinetti G, Neels JG. Roles of Nuclear Receptors in Vascular Calcification. International Journal of Molecular Sciences. 2021; 22(12):6491. https://doi.org/10.3390/ijms22126491

Chicago/Turabian Style

Chinetti, Giulia, and Jaap G. Neels 2021. "Roles of Nuclear Receptors in Vascular Calcification" International Journal of Molecular Sciences 22, no. 12: 6491. https://doi.org/10.3390/ijms22126491

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