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Review

Peptides Derived from Growth Factors to Treat Alzheimer’s Disease

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Laboratory of Cell-Biomaterial Biohybrid Systems, Department of Chemical and Biotechnological Engineering, 2500 Boulevard Université, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada
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Département de Pharmacologie-Physiologie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada
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Centre de Recherche sur le Vieillissement, Centre Intégré Universitaire de Santé et Services Sociaux de l’Estrie–Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC J1G 1B1, Canada
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Département de Médecine, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada
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Institut de Pharmacologie de Sherbrooke, 3001 12th Avenue, N., Sherbrooke, QC J1H 5N4, Canada
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Authors to whom correspondence should be addressed.
Academic Editor: Cristina Martínez-Villaluenga
Int. J. Mol. Sci. 2021, 22(11), 6071; https://doi.org/10.3390/ijms22116071
Received: 15 May 2021 / Revised: 30 May 2021 / Accepted: 1 June 2021 / Published: 4 June 2021
(This article belongs to the Special Issue Peptides for Health Benefits 2021)
Alzheimer’s disease (AD) is a devastating neurodegenerative disease characterized by progressive neuron losses in memory-related brain structures. The classical features of AD are a dysregulation of the cholinergic system, the accumulation of amyloid plaques, and neurofibrillary tangles. Unfortunately, current treatments are unable to cure or even delay the progression of the disease. Therefore, new therapeutic strategies have emerged, such as the exogenous administration of neurotrophic factors (e.g., NGF and BDNF) that are deficient or dysregulated in AD. However, their low capacity to cross the blood–brain barrier and their exorbitant cost currently limit their use. To overcome these limitations, short peptides mimicking the binding receptor sites of these growth factors have been developed. Such peptides can target selective signaling pathways involved in neuron survival, differentiation, and/or maintenance. This review focuses on growth factors and their derived peptides as potential treatment for AD. It describes (1) the physiological functions of growth factors in the brain, their neuronal signaling pathways, and alteration in AD; (2) the strategies to develop peptides derived from growth factor and their capacity to mimic the role of native proteins; and (3) new advancements and potential in using these molecules as therapeutic treatments for AD, as well as their limitations. View Full-Text
Keywords: neurotrophin; bone morphogenetic proteins; MAPK; PI3K/AKT; cholinergic neurons; amyloid-β peptide; tau protein; metabolic pathway neurotrophin; bone morphogenetic proteins; MAPK; PI3K/AKT; cholinergic neurons; amyloid-β peptide; tau protein; metabolic pathway
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MDPI and ACS Style

Gascon, S.; Jann, J.; Langlois-Blais, C.; Plourde, M.; Lavoie, C.; Faucheux, N. Peptides Derived from Growth Factors to Treat Alzheimer’s Disease. Int. J. Mol. Sci. 2021, 22, 6071. https://doi.org/10.3390/ijms22116071

AMA Style

Gascon S, Jann J, Langlois-Blais C, Plourde M, Lavoie C, Faucheux N. Peptides Derived from Growth Factors to Treat Alzheimer’s Disease. International Journal of Molecular Sciences. 2021; 22(11):6071. https://doi.org/10.3390/ijms22116071

Chicago/Turabian Style

Gascon, Suzanne, Jessica Jann, Chloé Langlois-Blais, Mélanie Plourde, Christine Lavoie, and Nathalie Faucheux. 2021. "Peptides Derived from Growth Factors to Treat Alzheimer’s Disease" International Journal of Molecular Sciences 22, no. 11: 6071. https://doi.org/10.3390/ijms22116071

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