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Volume 21
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10.3390/ijms21082928
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Review

The Distinct Roles of Transcriptional Factor KLF11 in Normal Cell Growth Regulation and Cancer as a Mediator of TGF-β Signaling Pathway

by
Lili Lin
1,
Sven Mahner
1,
Udo Jeschke
1,2,* and
Anna Hester
1
1
Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Marchioninistr. 15, 81377 Munich, Germany
2
Department of Gynecology and Obstetrics, University Hospital Augsburg, Stenglinstraße 2, 86156 Augsburg, Germany
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(8), 2928; https://doi.org/10.3390/ijms21082928
Submission received: 31 January 2020 / Revised: 20 April 2020 / Accepted: 21 April 2020 / Published: 22 April 2020
(This article belongs to the Special Issue TGF-Beta Super Family Signaling 2.0)
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Abstract

KLF11 (Krüppel-like factor 11) belongs to the family of Sp1/Krüppel-like zinc finger transcription factors that play important roles in a variety of cell types and tissues. KLF11 was initially described as a transforming growth factor-beta (TGF-β) inducible immediate early gene (TIEG). KLF11 promotes the effects of TGF-β on cell growth control by influencing the TGFβ–Smads signaling pathway and regulating the transcription of genes that induce either apoptosis or cell cycle arrest. In carcinogenesis, KLF11 can show diverse effects. Its function as a tumor suppressor gene can be suppressed by phosphorylation of its binding domains via oncogenic pathways. However, KLF 11 can itself also show tumor-promoting effects and seems to have a crucial role in the epithelial–mesenchymal transition process. Here, we review the current knowledge about the function of KLF11 in cell growth regulation. We focus on its transcriptional regulatory function and its influence on the TGF-β signaling pathway. We further discuss its possible role in mediating crosstalk between various signaling pathways in normal cell growth and in carcinogenesis.
Keywords: KLF11; TGF-β; TIEG; cell cycle; apoptosis; cell growth; cancer KLF11; TGF-β; TIEG; cell cycle; apoptosis; cell growth; cancer

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MDPI and ACS Style

Lin, L.; Mahner, S.; Jeschke, U.; Hester, A. The Distinct Roles of Transcriptional Factor KLF11 in Normal Cell Growth Regulation and Cancer as a Mediator of TGF-β Signaling Pathway. Int. J. Mol. Sci. 2020, 21, 2928. https://doi.org/10.3390/ijms21082928

AMA Style

Lin L, Mahner S, Jeschke U, Hester A. The Distinct Roles of Transcriptional Factor KLF11 in Normal Cell Growth Regulation and Cancer as a Mediator of TGF-β Signaling Pathway. International Journal of Molecular Sciences. 2020; 21(8):2928. https://doi.org/10.3390/ijms21082928

Chicago/Turabian Style

Lin, Lili, Sven Mahner, Udo Jeschke, and Anna Hester. 2020. "The Distinct Roles of Transcriptional Factor KLF11 in Normal Cell Growth Regulation and Cancer as a Mediator of TGF-β Signaling Pathway" International Journal of Molecular Sciences 21, no. 8: 2928. https://doi.org/10.3390/ijms21082928

APA Style

Lin, L., Mahner, S., Jeschke, U., & Hester, A. (2020). The Distinct Roles of Transcriptional Factor KLF11 in Normal Cell Growth Regulation and Cancer as a Mediator of TGF-β Signaling Pathway. International Journal of Molecular Sciences, 21(8), 2928. https://doi.org/10.3390/ijms21082928

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