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Review

Dynamics Studies of DNA with Non-canonical Structure Using NMR Spectroscopy

by
Kwang-Im Oh
1,†,
Jinwoo Kim
2,†,
Chin-Ju Park
2,* and
Joon-Hwa Lee
1,*
1
Department of Chemistry and RINS, Gyeongsang National University, Gyeongnam 52828, Korea
2
Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Korea
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(8), 2673; https://doi.org/10.3390/ijms21082673
Submission received: 23 March 2020 / Revised: 7 April 2020 / Accepted: 9 April 2020 / Published: 11 April 2020
(This article belongs to the Special Issue Selected Papers from the 8th Asia-Pacific NMR Symposium (APNMR): Recent Advances in NMR Spectroscopy)
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Abstract

The non-canonical structures of nucleic acids are essential for their diverse functions during various biological processes. These non-canonical structures can undergo conformational exchange among multiple structural states. Data on their dynamics can illustrate conformational transitions that play important roles in folding, stability, and biological function. Here, we discuss several examples of the non-canonical structures of DNA focusing on their dynamic characterization by NMR spectroscopy: (1) G-quadruplex structures and their complexes with target proteins; (2) i-motif structures and their complexes with proteins; (3) triplex structures; (4) left-handed Z-DNAs and their complexes with various Z-DNA binding proteins. This review provides insight into how the dynamic features of non-canonical DNA structures contribute to essential biological processes.
Keywords: nucleic acids; NMR; G-quadruplex; I-motif; triple helix; Z-DNA; dynamics nucleic acids; NMR; G-quadruplex; I-motif; triple helix; Z-DNA; dynamics

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MDPI and ACS Style

Oh, K.-I.; Kim, J.; Park, C.-J.; Lee, J.-H. Dynamics Studies of DNA with Non-canonical Structure Using NMR Spectroscopy. Int. J. Mol. Sci. 2020, 21, 2673. https://doi.org/10.3390/ijms21082673

AMA Style

Oh K-I, Kim J, Park C-J, Lee J-H. Dynamics Studies of DNA with Non-canonical Structure Using NMR Spectroscopy. International Journal of Molecular Sciences. 2020; 21(8):2673. https://doi.org/10.3390/ijms21082673

Chicago/Turabian Style

Oh, Kwang-Im, Jinwoo Kim, Chin-Ju Park, and Joon-Hwa Lee. 2020. "Dynamics Studies of DNA with Non-canonical Structure Using NMR Spectroscopy" International Journal of Molecular Sciences 21, no. 8: 2673. https://doi.org/10.3390/ijms21082673

APA Style

Oh, K.-I., Kim, J., Park, C.-J., & Lee, J.-H. (2020). Dynamics Studies of DNA with Non-canonical Structure Using NMR Spectroscopy. International Journal of Molecular Sciences, 21(8), 2673. https://doi.org/10.3390/ijms21082673

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