Next Article in Journal
Recent Overview of the Use of iPSCs Huntington’s Disease Modeling and Therapy
Next Article in Special Issue
The ULK1/2 and AMPK Inhibitor SBI-0206965 Blocks AICAR and Insulin-Stimulated Glucose Transport
Previous Article in Journal
Analysis of the Activity and Expression of Cyclooxygenases COX1 and COX2 in THP-1 Monocytes and Macrophages Cultured with BiodentineTM Silicate Cement
Previous Article in Special Issue
Norepinephrine Regulation of Ventromedial Hypothalamic Nucleus Metabolic-Sensory Neuron 5′-AMP-Activated Protein Kinase Activity: Impact of Estradiol
Open AccessReview

AMPK Regulates Developmental Plasticity through an Endogenous Small RNA Pathway in Caenorhabditis elegans

Department of Biology, McGill University, Montreal, QC H3A 1B1, Canada
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(6), 2238; https://doi.org/10.3390/ijms21062238
Received: 1 March 2020 / Revised: 18 March 2020 / Accepted: 22 March 2020 / Published: 24 March 2020
(This article belongs to the Special Issue AMP-Activated Protein Kinase Signalling 2.0)
Caenorhabditis elegans larvae can undergo developmental arrest upon entry into the dauer stage in response to suboptimal growth conditions. Dauer larvae can exit this stage in replete conditions with no reproductive consequence. During this diapause stage, the metabolic regulator AMP-activated protein kinase (AMPK) ensures that the germ line becomes quiescent to maintain germ cell integrity. Animals that lack all AMPK signalling undergo germline hyperplasia upon entering dauer, while those that recover from this stage become sterile. Neuronal AMPK expression in otherwise AMPK-deficient animals is sufficient for germline quiescence and germ cell integrity and its effects are likely mediated through an endogenous small RNA pathway. Upon impairing small RNA biosynthesis, the post-dauer fertility is restored in AMPK mutants. These data suggest that AMPK may function in neurons to relay a message through small RNAs to the germ cells to alter their quiescence in the dauer stage, thus challenging the permeability of the Weismann barrier. View Full-Text
Keywords: germ line; quiescence; small RNA; chromatin remodelling; dauer; C. elegans germ line; quiescence; small RNA; chromatin remodelling; dauer; C. elegans
Show Figures

Figure 1

MDPI and ACS Style

Wong, C.; Roy, R. AMPK Regulates Developmental Plasticity through an Endogenous Small RNA Pathway in Caenorhabditis elegans. Int. J. Mol. Sci. 2020, 21, 2238.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop