Extracellular Vesicles in Feto–Maternal Crosstalk and Pregnancy Disorders
by
Danilo Buca 1,*,†, Giuseppina Bologna 2,3,†, Alice D’Amico 1, Sara Cugini 4, Francesca Musca 4, Melania Febbo 4, Dolores D’Arcangelo 4, Davide Buca 5, Pasquale Simeone 2,3
, Marco Liberati 1, Ester Vitacolonna 2, Sebastiano Miscia 2,3, Francesco D’Antonio 6 and Paola Lanuti 2,3
Danilo Buca 1,*,†, Giuseppina Bologna 2,3,†, Alice D’Amico 1, Sara Cugini 4, Francesca Musca 4, Melania Febbo 4, Dolores D’Arcangelo 4, Davide Buca 5, Pasquale Simeone 2,3, Marco Liberati 1, Ester Vitacolonna 2, Sebastiano Miscia 2,3, Francesco D’Antonio 6 and Paola Lanuti 2,3
1
Department of Obstetrics and Gynecology, University of Chieti, 66100 Chieti, Italy
2
Department of Medicine and Aging Sciences, University “G. d’Annunzio” of Chieti-Pescara, 66100 Chieti, Italy
3
Centre on Aging Sciences and Translational Medicine (Ce.S.I.-Me.T.), University “G. D’Annunzio” of Chieti-Pescara, 66100 Chieti, Italy
4
School of Medicine and Health Science, G. d’Annunzio University of Chieti-Pescara, 66100 Chieti, Italy
5
Department of Molecular Medicine and Development, University of Siena, 53100 Siena, Italy
6
Fetal Medicine Unit, Department of Medical and Surgical Sciences, Department of Obstetrics and Gynecology, University of Foggia, 71121 Foggia, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(6), 2120; https://doi.org/10.3390/ijms21062120
Received: 17 February 2020 / Revised: 14 March 2020 / Accepted: 18 March 2020 / Published: 19 March 2020
(This article belongs to the Section Biochemistry)
Extracellular vesicles (EVs) actively participate in inter-cellular crosstalk and have progressively emerged as key players of organized communities of cells within multicellular organisms in health and disease. For these reasons, EVs are attracting the attention of many investigators across different biomedical fields. In this scenario, the possibility to study specific placental-derived EVs in the maternal peripheral blood may open novel perspectives in the development of new early biomarkers for major obstetric pathological conditions. Here we reviewed the involvement of EVs in feto–maternal crosstalk mechanisms, both in physiological and pathological conditions (preeclampsia, fetal growth restriction, preterm labor, gestational diabetes mellitus), also underlining the usefulness of EV characterization in maternal–fetal medicine.
View Full-Text
Keywords:
placental extracellular vesicles; syncytiotrophoblast; preterm-labor; pre-eclampsia; gestational diabetes mellitus; fetal growth restriction
▼
Show Figures
Figure 1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Buca, D.; Bologna, G.; D’Amico, A.; Cugini, S.; Musca, F.; Febbo, M.; D’Arcangelo, D.; Buca, D.; Simeone, P.; Liberati, M.; Vitacolonna, E.; Miscia, S.; D’Antonio, F.; Lanuti, P. Extracellular Vesicles in Feto–Maternal Crosstalk and Pregnancy Disorders. Int. J. Mol. Sci. 2020, 21, 2120.
Show more citation formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
Search more from Scilit
