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Review

Neutrophils as a Novel Target of Modified Low-Density Lipoproteins and an Accelerator of Cardiovascular Diseases

Division of Biological Chemistry, Department of Pharmaceutical Sciences, Showa University School of Pharmacy, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan
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Int. J. Mol. Sci. 2020, 21(21), 8312; https://doi.org/10.3390/ijms21218312
Received: 30 September 2020 / Revised: 31 October 2020 / Accepted: 3 November 2020 / Published: 5 November 2020
Neutrophil extracellular traps (NETs) significantly contribute to various pathophysiological conditions, including cardiovascular diseases. NET formation in the vasculature exhibits inflammatory and thrombogenic activities on the endothelium. NETs are induced by various stimulants such as exogenous damage-associated molecular patterns (DAMPs). Oxidatively modified low-density lipoprotein (oxLDL) has been physiologically defined as a subpopulation of LDL that comprises various oxidative modifications in the protein components and oxidized lipids, which could act as DAMPs. oxLDL has been recognized as a crucial initiator and accelerator of atherosclerosis through foam cell formation by macrophages; however, recent studies have demonstrated that oxLDL stimulates neutrophils to induce NET formation and enhance NET-mediated inflammatory responses in vascular endothelial cells, thereby suggesting that oxLDL may be involved in cardiovascular diseases through neutrophil activation. As NETs comprise myeloperoxidase and proteases, they have the potential to mediate oxidative modification of LDL. This review summarizes recent updates on the analysis of NETs, their implications for cardiovascular diseases, and prospects for a possible link between NET formation and oxidative modification of lipoproteins. View Full-Text
Keywords: neutrophil extracellular traps; oxidized low-density lipoprotein; endothelial cells; HL-60 cells; inflammatory response neutrophil extracellular traps; oxidized low-density lipoprotein; endothelial cells; HL-60 cells; inflammatory response
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MDPI and ACS Style

Obama, T.; Itabe, H. Neutrophils as a Novel Target of Modified Low-Density Lipoproteins and an Accelerator of Cardiovascular Diseases. Int. J. Mol. Sci. 2020, 21, 8312. https://doi.org/10.3390/ijms21218312

AMA Style

Obama T, Itabe H. Neutrophils as a Novel Target of Modified Low-Density Lipoproteins and an Accelerator of Cardiovascular Diseases. International Journal of Molecular Sciences. 2020; 21(21):8312. https://doi.org/10.3390/ijms21218312

Chicago/Turabian Style

Obama, Takashi, and Hiroyuki Itabe. 2020. "Neutrophils as a Novel Target of Modified Low-Density Lipoproteins and an Accelerator of Cardiovascular Diseases" International Journal of Molecular Sciences 21, no. 21: 8312. https://doi.org/10.3390/ijms21218312

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