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Post-Transcriptional Expression Control in Platelet Biogenesis and Function

1
Institute of Pathology, Section for Experimental Pathology, Medical Faculty, Martin-Luther University Halle-Wittenberg, 06120 Halle/Saale, Germany
2
Junior Research Group ‘RNA Biology and Pathogenesis’, Medical Faculty, Martin-Luther University Halle-Wittenberg, 06120 Halle/Saale, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this manuscript.
Int. J. Mol. Sci. 2020, 21(20), 7614; https://doi.org/10.3390/ijms21207614
Received: 6 September 2020 / Revised: 6 October 2020 / Accepted: 13 October 2020 / Published: 15 October 2020
(This article belongs to the Special Issue RNA-Binding Proteins in Human Diseases—from Mechanisms to Therapies)
Platelets are highly abundant cell fragments of the peripheral blood that originate from megakaryocytes. Beside their well-known role in wound healing and hemostasis, they are emerging mediators of the immune response and implicated in a variety of pathophysiological conditions including cancer. Despite their anucleate nature, they harbor a diverse set of RNAs, which are subject to an active sorting mechanism from megakaryocytes into proplatelets and affect platelet biogenesis and function. However, sorting mechanisms are poorly understood, but RNA-binding proteins (RBPs) have been suggested to play a crucial role. Moreover, RBPs may regulate RNA translation and decay following platelet activation. In concert with other regulators, including microRNAs, long non-coding and circular RNAs, RBPs control multiple steps of the platelet life cycle. In this review, we will highlight the different RNA species within platelets and their impact on megakaryopoiesis, platelet biogenesis and platelet function. Additionally, we will focus on the currently known concepts of post-transcriptional control mechanisms important for RNA fate within platelets with a special emphasis on RBPs. View Full-Text
Keywords: RBP; miRNA; lncRNA; circRNA; platelets; thrombosis; posttranscriptional regulation RBP; miRNA; lncRNA; circRNA; platelets; thrombosis; posttranscriptional regulation
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MDPI and ACS Style

Neu, C.T.; Gutschner, T.; Haemmerle, M. Post-Transcriptional Expression Control in Platelet Biogenesis and Function. Int. J. Mol. Sci. 2020, 21, 7614. https://doi.org/10.3390/ijms21207614

AMA Style

Neu CT, Gutschner T, Haemmerle M. Post-Transcriptional Expression Control in Platelet Biogenesis and Function. International Journal of Molecular Sciences. 2020; 21(20):7614. https://doi.org/10.3390/ijms21207614

Chicago/Turabian Style

Neu, Carolin T.; Gutschner, Tony; Haemmerle, Monika. 2020. "Post-Transcriptional Expression Control in Platelet Biogenesis and Function" Int. J. Mol. Sci. 21, no. 20: 7614. https://doi.org/10.3390/ijms21207614

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