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Open AccessArticle

Moderate Aerobic Exercise Training Prevents the Augmented Hepatic Glucocorticoid Response Induced by High-Fat Diet in Mice

1
Laboratorio de Investigación en Nutrición y Actividad Física (LABINAF), Instituto de Nutrición y Tecnologia de los Alimentos (INTA), Universidad de Chile, Santiago 7830490, Chile
2
Departamento de Tecnología Medica, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile
3
Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Universidad de Chile, Santiago 8380492, Chile
4
Laboratorio de Nutrición y Regulación Metabólica, INTA, Universidad de Chile, Santiago 7830490, Chile
*
Author to whom correspondence should be addressed.
These authors contributed equally to work.
Int. J. Mol. Sci. 2020, 21(20), 7582; https://doi.org/10.3390/ijms21207582
Received: 13 August 2020 / Revised: 22 September 2020 / Accepted: 7 October 2020 / Published: 14 October 2020
(This article belongs to the Special Issue Exercise-Induced Hormonal Modifications)
Glucocorticoids (GCs) are critical regulators of energy balance. Their deregulation is associated with the development of obesity and metabolic syndrome. However, it is not understood if obesity alters the tissue glucocorticoid receptor (GR) response, and moreover whether a moderate aerobic exercise prevents the alteration in GR response induced by obesity. Methods: To evaluate the GR response in obese mice, we fed C57BL6J mice with a high-fat diet (HFD) for 12 weeks. Before mice were sacrificed, we injected them with dexamethasone. To assess the exercise role in GR response, we fed mice an HFD and subjected them to moderate aerobic exercise three times a week. Results: We found that mice fed a high-fat diet for 12 weeks developed hepatic GC hypersensitivity without changes in the gastrocnemius or epididymal fat GR response. Therefore, moderate aerobic exercise improved glucose tolerance, increased the corticosterone plasma levels, and prevented hepatic GR hypersensitivity with an increase in epididymal fat GR response. Conclusion: Collectively, our results suggest that mice with HFD-induced obesity develop hepatic GR sensitivity, which could enhance the metabolic effects of HFD in the liver. Moreover, exercise was found to be a feasible non-pharmacological strategy to prevent the deregulation of GR response in obesity. View Full-Text
Keywords: glucocorticoids; FKBP51; liver; obesity; exercise glucocorticoids; FKBP51; liver; obesity; exercise
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MDPI and ACS Style

Dassonvalle, J.; Díaz-Castro, F.; Donoso-Barraza, C.; Sepúlveda, C.; Pino-de la Fuente, F.; Pino, P.; Espinosa, A.; Chiong, M.; Llanos, M.; Troncoso, R. Moderate Aerobic Exercise Training Prevents the Augmented Hepatic Glucocorticoid Response Induced by High-Fat Diet in Mice. Int. J. Mol. Sci. 2020, 21, 7582. https://doi.org/10.3390/ijms21207582

AMA Style

Dassonvalle J, Díaz-Castro F, Donoso-Barraza C, Sepúlveda C, Pino-de la Fuente F, Pino P, Espinosa A, Chiong M, Llanos M, Troncoso R. Moderate Aerobic Exercise Training Prevents the Augmented Hepatic Glucocorticoid Response Induced by High-Fat Diet in Mice. International Journal of Molecular Sciences. 2020; 21(20):7582. https://doi.org/10.3390/ijms21207582

Chicago/Turabian Style

Dassonvalle, Jonatan; Díaz-Castro, Francisco; Donoso-Barraza, Camila; Sepúlveda, Carlos; Pino-de la Fuente, Francisco; Pino, Pamela; Espinosa, Alejandra; Chiong, Mario; Llanos, Miguel; Troncoso, Rodrigo. 2020. "Moderate Aerobic Exercise Training Prevents the Augmented Hepatic Glucocorticoid Response Induced by High-Fat Diet in Mice" Int. J. Mol. Sci. 21, no. 20: 7582. https://doi.org/10.3390/ijms21207582

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