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The Role of α1-Microglobulin (A1M) in Erythropoiesis and Erythrocyte Homeostasis—Therapeutic Opportunities in Hemolytic Conditions

1
Section for Infection Medicine, Department of Clinical Sciences, Lund University, 221 84 Lund, Sweden
2
Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University, 221 84 Lund, Sweden
3
Department of Clinical Sciences Lund, Pediatrics, Lund University, 221 84 Lund, Sweden
4
Department of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, 221 84 Lund, Sweden
5
Department of Obstetrics and Gynecology, Institute of Clinical Sciences Lund, Lund University, 221 84 Lund, Sweden
6
Department of Clinical Immunology and Transfusion Medicine, Office of Medical Services, 221 85 Lund, Sweden
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(19), 7234; https://doi.org/10.3390/ijms21197234
Received: 14 September 2020 / Revised: 28 September 2020 / Accepted: 29 September 2020 / Published: 30 September 2020
(This article belongs to the Special Issue Heme- and Hemoglobin Stress in Human Diseases)
α1-microglobulin (A1M) is a small protein present in vertebrates including humans. It has several physiologically relevant properties, including binding of heme and radicals as well as enzymatic reduction, that are used in the protection of cells and tissue. Research has revealed that A1M can ameliorate heme and ROS-induced injuries in cell cultures, organs, explants and animal models. Recently, it was shown that A1M could reduce hemolysis in vitro, observed with several different types of insults and sources of RBCs. In addition, in a recently published study, it was observed that mice lacking A1M (A1M-KO) developed a macrocytic anemia phenotype. Altogether, this suggests that A1M may have a role in RBC development, stability and turnover. This opens up the possibility of utilizing A1M for therapeutic purposes in pathological conditions involving erythropoietic and hemolytic abnormalities. Here, we provide an overview of A1M and its potential therapeutic effect in the context of the following erythropoietic and hemolytic conditions: Diamond-Blackfan anemia (DBA), 5q-minus myelodysplastic syndrome (5q-MDS), blood transfusions (including storage), intraventricular hemorrhage (IVH), preeclampsia (PE) and atherosclerosis. View Full-Text
Keywords: α1-microglobulin (A1M); red blood cells; hemolysis; heme; Diamond-Blackfan anemia; 5q-minus myelodysplastic syndrome; blood transfusions; intraventricular hemorrhage; preeclampsia; atherosclerosis α1-microglobulin (A1M); red blood cells; hemolysis; heme; Diamond-Blackfan anemia; 5q-minus myelodysplastic syndrome; blood transfusions; intraventricular hemorrhage; preeclampsia; atherosclerosis
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MDPI and ACS Style

Kristiansson, A.; Gram, M.; Flygare, J.; Hansson, S.R.; Åkerström, B.; Storry, J.R. The Role of α1-Microglobulin (A1M) in Erythropoiesis and Erythrocyte Homeostasis—Therapeutic Opportunities in Hemolytic Conditions. Int. J. Mol. Sci. 2020, 21, 7234. https://doi.org/10.3390/ijms21197234

AMA Style

Kristiansson A, Gram M, Flygare J, Hansson SR, Åkerström B, Storry JR. The Role of α1-Microglobulin (A1M) in Erythropoiesis and Erythrocyte Homeostasis—Therapeutic Opportunities in Hemolytic Conditions. International Journal of Molecular Sciences. 2020; 21(19):7234. https://doi.org/10.3390/ijms21197234

Chicago/Turabian Style

Kristiansson, Amanda, Magnus Gram, Johan Flygare, Stefan R. Hansson, Bo Åkerström, and Jill R. Storry. 2020. "The Role of α1-Microglobulin (A1M) in Erythropoiesis and Erythrocyte Homeostasis—Therapeutic Opportunities in Hemolytic Conditions" International Journal of Molecular Sciences 21, no. 19: 7234. https://doi.org/10.3390/ijms21197234

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