Emerging Roles of BRD7 in Pathophysiology
1
Division of Endocrinology, Boston Children’s Hospital, Boston, MA 02115, USA
2
Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(19), 7127; https://doi.org/10.3390/ijms21197127
Received: 7 September 2020 / Revised: 20 September 2020 / Accepted: 23 September 2020 / Published: 27 September 2020
(This article belongs to the Special Issue Progress in Glucose Metabolism)
Bromodomain is a conserved structural module found in many chromatin-associated proteins. Bromodomain-containing protein 7 (BRD7) is a member of the bromodomain-containing protein family, and was discovered two decades ago as a protein that is downregulated in nasopharyngeal carcinoma. Since then, BRD7 has been implicated in a variety of cellular processes, including chromatin remodeling, transcriptional regulation, and cell cycle progression. Decreased BRD7 activity underlies the pathophysiological properties of various diseases in different organs. BRD7 plays an important role in the pathogenesis of many cancers and, more recently, its roles in the regulation of metabolism and obesity have also been highlighted. Here, we review the involvement of BRD7 in a variety of pathophysiological conditions, with a focus on glucose homeostasis, obesity, and cancer.
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Keywords:
BRD7; glucose metabolism; type 2 diabetes; XBP1s; PI3K; p85; cancer
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MDPI and ACS Style
Park, S.W.; Lee, J.M. Emerging Roles of BRD7 in Pathophysiology. Int. J. Mol. Sci. 2020, 21, 7127. https://doi.org/10.3390/ijms21197127
AMA Style
Park SW, Lee JM. Emerging Roles of BRD7 in Pathophysiology. International Journal of Molecular Sciences. 2020; 21(19):7127. https://doi.org/10.3390/ijms21197127
Chicago/Turabian StylePark, Sang W.; Lee, Junsik M. 2020. "Emerging Roles of BRD7 in Pathophysiology" Int. J. Mol. Sci. 21, no. 19: 7127. https://doi.org/10.3390/ijms21197127
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