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Review

PAI-1, the Plasminogen System, and Skeletal Muscle

1
Department of Kinesiology, University of Waterloo, Waterloo, ON N2L 3G5, Canada
2
Department of Kinesiology, University of Windsor, Windsor, ON N9B 3P4, Canada
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(19), 7066; https://doi.org/10.3390/ijms21197066
Received: 28 August 2020 / Revised: 21 September 2020 / Accepted: 23 September 2020 / Published: 25 September 2020
(This article belongs to the Special Issue Extracellular Matrix in Development and Disease 2.0)
The plasminogen system is a critical proteolytic system responsible for the remodeling of the extracellular matrix (ECM). The master regulator of the plasminogen system, plasminogen activator inhibitor-1 (PAI-1), has been implicated for its role in exacerbating various disease states not only through the accumulation of ECM (i.e., fibrosis) but also its role in altering cell fate/behaviour. Examination of PAI-1 has extended through various tissues and cell-types with recent investigations showing its presence in skeletal muscle. In skeletal muscle, the role of this protein has been implicated throughout the regeneration process, and in skeletal muscle pathologies (muscular dystrophy, diabetes, and aging-driven pathology). Needless to say, the complete function of this protein in skeletal muscle has yet to be fully elucidated. Given the importance of skeletal muscle in maintaining overall health and quality of life, it is critical to understand the alterations—particularly in PAI-1—that occur to negatively impact this organ. Thus, we provide a comprehensive review of the importance of PAI-1 in skeletal muscle health and function. We aim to shed light on the relevance of this protein in skeletal muscle and propose potential therapeutic approaches to aid in the maintenance of skeletal muscle health. View Full-Text
Keywords: plasminogen activator inhibitor-1; plasminogen system; skeletal muscle; pathophysiology; regeneration; muscular dystrophy; diabetes; aging; exercise; therapeutics plasminogen activator inhibitor-1; plasminogen system; skeletal muscle; pathophysiology; regeneration; muscular dystrophy; diabetes; aging; exercise; therapeutics
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MDPI and ACS Style

Rahman, F.A.; Krause, M.P. PAI-1, the Plasminogen System, and Skeletal Muscle. Int. J. Mol. Sci. 2020, 21, 7066. https://doi.org/10.3390/ijms21197066

AMA Style

Rahman FA, Krause MP. PAI-1, the Plasminogen System, and Skeletal Muscle. International Journal of Molecular Sciences. 2020; 21(19):7066. https://doi.org/10.3390/ijms21197066

Chicago/Turabian Style

Rahman, Fasih Ahmad, and Matthew Paul Krause. 2020. "PAI-1, the Plasminogen System, and Skeletal Muscle" International Journal of Molecular Sciences 21, no. 19: 7066. https://doi.org/10.3390/ijms21197066

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