Regulation of microRNAs in Satellite Cell Renewal, Muscle Function, Sarcopenia and the Role of Exercise
Abstract
:1. Introduction
2. miRNA Biogenesis and Functional Role
3. Skeletal Myogenesis and Sarcopenia
4. The Role of miRNAs during Skeletal Myogenesis in Adults
4.1. miRNAs Role in the Control of Satellite Cells Quiescence Status
4.2. miRNAs Role in Myogenesis
5. Role of miRNAs in Skeletal Muscle Aging and Sarcopenia
6. miRNAs Are Regulated by Exercise in Sarcopenia
6.1. Exercise Modulates Muscle miRNAs Expression
6.2. Exercise Modulates Circulating miRNAs Expression
7. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Subjects | Type of Exercise | Duration a | MyomiRs | Other miRNAs | References |
---|---|---|---|---|---|
Older man(70 yr) | Resistance acute exercise bout | 3/6 hrs | ↓miR-1 | [94] | |
30–35 yr old healthy, trained men | Endurance acute exercise bout | 1 hr | ↑miR-1, miR-133a/b, miR-206 | [132] | |
Endurance training | 12 wks | ↓miR-1, miR-133a/b, miR-206 | |||
18–30 yr old men (low responders) | Resistance exercise training | 12 wks | ↑miR-451, ↓miR-26a, miR-29a, miR-378 | [143] | |
24 yr old young sedentary healthy men | Endurance training | 6 wks | ↓miR-1, miR-133a | ↓miR-101, miR-455 | [131] |
Males 23 yr old | Endurance acute exercise bout | 3 hrs | ↑miR-1, miR-133a/b, miR-206 | ↑miR-181a, ↓miR-9, miR-23a/b, miR-31 | [133] |
Healthy young (18–30 yr old) and older (60–75 yr) men | Resistance acute exercise bout | 2 hrs | Young | [136] | |
↑miR-486-3p, | ↓miR-149-3p, miR-520g-3p, miR-99b-5p, miR-100-5p | ||||
Old | |||||
↑miR-499a-5p | ↑ miR-99a-5p, ↓miR-186-5p, miR-196b, miR-335-5p, miR-628-5p, miR-489-5p | ||||
Young, healthy (22 yr) and old (74 yr) men | Resistance acute exercise bout | 6 hrs | Young | [135] | |
↓miR-133a, miR-133b | ↓miR-23b-3p, miR-24-3p, miR-26a-5p, miR-26b-5p, miR-27a-3p, miR-27b-3p, miR-29c-3p, miR-30a-5p, miR-30d-5p, miR-95-3p, miR-126-3p, miR-140-3p, miR-181a-5p | ||||
Older men and women (65–80 yr) | Resistance exercise training | 5 mos | ↓miR-133b | [142] | |
Sedentary Healthy men and women (31–35 yr old) | Resistance acute exercise bout | 30 min | ↑miR-10a-5p, miR-30a-5p, miR-30d-5p, miR-22-3p, miR-128, miR-378a-3p, miR-378f, miR-378a-5p, miR-378g, miR-378i, miR-422a, miR-532-5p | [138] | |
Healthy males (23–31 yr old) | HIIT or MICT b + RE | 1/3 hrs | ↓miR-486, miR-133a | ↓miR-378 | [141] |
25 adults (18–27 yr old) | Endurance single 90 min exercise bout (Load carriage or cycle ergometry) | Immediately/3 hrs | ↓miR-1-3p, miR-206, miR-208a-5, miR-499 | [134] |
Subjects | Type of Exercise | Duration a | c-miRNAs b | Reference | |
---|---|---|---|---|---|
Male marathon runners (51.6–62 yr old) | Endurance acute exercise bout | 30 min/4 hrs | Immediately post-exercise: ↑miR-126, miR-133 | [157] | |
Male marathon runners (50.4–53.2 yr old) | Endurance acute exercise bout | Immediately post/up to 24 hrs | Immediately post exercise: ↑miR-1, miR-126, miR-133a, miR-134, miR-146a, miR-208a, miR-499-5p | [158] | |
Healthy, inactive, young (21–23 yr) and old (72–76 yr) | Resistance acute exercise bout | 6 hrs | Young ↑miR-19b-3p, miR-195-5p, miR-19a-3p, miR-106-5p, miR-20a-5p, miR-17-5p, miR-143-3p, miR-26b-5p, miR-93-5p | [155] | |
Low (40.6–52 yr) and high (42–54.4 yr) responding men and women to a weight loss intervention | Resistance exercise training and diet intervention | 16 wks | Both groups: ↑221-3p, 223-3p Only Low responder: ↑miR-140 | [159] | |
Older trained and older sedentary men (>65 yr old) | Endurance acute exercise bout | 40 min | Trained group | [160] | |
Immediately post exercise ↑miR-383-5p, miR-339-5p, miR-874-3p ↓miR-206, miR-486-5p, miR-148a-3p, let-7b-5p | 3 hrs post exercise↑miR-34b-3p, miR-129-2-3p, miR-138-1-3p, miR-671-3p, miR-885-5p ↓miR-486-5p, miR-629-5p, miR-16-2-3p | ||||
Sedentary group | |||||
Immediately post exercise ↑ miR-505-3p, miR-29b-3p, miR-203a-3p, miR-384, miR-451a, miR-223-3p, miR-218-5p, miR-495-3p | 3 hrs post exercise ↓miR-4433b-3p, miR-378c, miR-151b, miR-151a-5p, hsa- miR-151b |
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Fochi, S.; Giuriato, G.; De Simone, T.; Gomez-Lira, M.; Tamburin, S.; Del Piccolo, L.; Schena, F.; Venturelli, M.; Romanelli, M.G. Regulation of microRNAs in Satellite Cell Renewal, Muscle Function, Sarcopenia and the Role of Exercise. Int. J. Mol. Sci. 2020, 21, 6732. https://doi.org/10.3390/ijms21186732
Fochi S, Giuriato G, De Simone T, Gomez-Lira M, Tamburin S, Del Piccolo L, Schena F, Venturelli M, Romanelli MG. Regulation of microRNAs in Satellite Cell Renewal, Muscle Function, Sarcopenia and the Role of Exercise. International Journal of Molecular Sciences. 2020; 21(18):6732. https://doi.org/10.3390/ijms21186732
Chicago/Turabian StyleFochi, Stefania, Gaia Giuriato, Tonia De Simone, Macarena Gomez-Lira, Stefano Tamburin, Lidia Del Piccolo, Federico Schena, Massimo Venturelli, and Maria Grazia Romanelli. 2020. "Regulation of microRNAs in Satellite Cell Renewal, Muscle Function, Sarcopenia and the Role of Exercise" International Journal of Molecular Sciences 21, no. 18: 6732. https://doi.org/10.3390/ijms21186732