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Open AccessArticle

Plant Natural Sources of the Endocannabinoid (E)-β-Caryophyllene: A Systematic Quantitative Analysis of Published Literature

Department of Life Sciences and Systems Biology, University of Turin, Via Quarello 15/a, 10135 Turin, Italy
This work is dedicated to Husnu Can Baser for his 70th birthday.
Int. J. Mol. Sci. 2020, 21(18), 6540; https://doi.org/10.3390/ijms21186540
Received: 7 August 2020 / Revised: 3 September 2020 / Accepted: 4 September 2020 / Published: 7 September 2020
(E)-β-caryophyllene (BCP) is a natural sesquiterpene hydrocarbon present in hundreds of plant species. BCP possesses several important pharmacological activities, ranging from pain treatment to neurological and metabolic disorders. These are mainly due to its ability to interact with the cannabinoid receptor 2 (CB2) and the complete lack of interaction with the brain CB1. A systematic analysis of plant species with essential oils containing a BCP percentage > 10% provided almost 300 entries with species belonging to 51 families. The essential oils were found to be extracted from 13 plant parts and samples originated from 56 countries worldwide. Statistical analyses included the evaluation of variability in BCP% and yield% as well as the statistical linkage between families, plant parts and countries of origin by cluster analysis. Identified species were also grouped according to their presence in the Belfrit list. The survey evidences the importance of essential oil yield evaluation in support of the chemical analysis. The results provide a comprehensive picture of the species with the highest BCP and yield percentages. View Full-Text
Keywords: plant species; essential oil; yield; percentages of (E)-β-caryophyllene; Belfrit list; plant part; geographical origin plant species; essential oil; yield; percentages of (E)-β-caryophyllene; Belfrit list; plant part; geographical origin
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MDPI and ACS Style

Maffei, M.E. Plant Natural Sources of the Endocannabinoid (E)-β-Caryophyllene: A Systematic Quantitative Analysis of Published Literature. Int. J. Mol. Sci. 2020, 21, 6540. https://doi.org/10.3390/ijms21186540

AMA Style

Maffei ME. Plant Natural Sources of the Endocannabinoid (E)-β-Caryophyllene: A Systematic Quantitative Analysis of Published Literature. International Journal of Molecular Sciences. 2020; 21(18):6540. https://doi.org/10.3390/ijms21186540

Chicago/Turabian Style

Maffei, Massimo E. 2020. "Plant Natural Sources of the Endocannabinoid (E)-β-Caryophyllene: A Systematic Quantitative Analysis of Published Literature" Int. J. Mol. Sci. 21, no. 18: 6540. https://doi.org/10.3390/ijms21186540

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