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Volume 21
Issue 18
10.3390/ijms21186502
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Review

New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy

by
Adrian H. Teruel
1,2,
Isabel Gonzalez-Alvarez
3,
Marival Bermejo
3,
Virginia Merino
1,4,
Maria Dolores Marcos
1,2,5,
Felix Sancenon
1,2,5,
Marta Gonzalez-Alvarez
3,*,† and
Ramon Martinez-Mañez
1,2,5
1
Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, 46022 Valencia, Spain
2
CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 46022 Valencia, Spain
3
Engineering Department, Pharmacy and Pharmaceutical Technology Section, Miguel Hernandez University, 03550 Alicante, Spain
4
Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, 46100 Valencia, Spain
5
Departamento de Química, Universitat Politècnica de València, Camí de Vera s/n, 46022 Valencia, Spain
*
Author to whom correspondence should be addressed.
†
Current address: Edificio Muhammad Al-Shafra, Facultad de Farmacia, UMH, Carretera Alicante Valencia km 87, 03550 San Juan de Alicante, 03550 Alicante, Spain.
Int. J. Mol. Sci. 2020, 21(18), 6502; https://doi.org/10.3390/ijms21186502
Submission received: 14 July 2020 / Revised: 25 August 2020 / Accepted: 2 September 2020 / Published: 5 September 2020
(This article belongs to the Section Molecular Pharmacology)
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Abstract

Colonic Drug Delivery Systems (CDDS) are especially advantageous for local treatment of inflammatory bowel diseases (IBD). Site-targeted drug release allows to obtain a high drug concentration in injured tissues and less systemic adverse effects, as consequence of less/null drug absorption in small intestine. This review focused on the reported contributions in the last four years to improve the effectiveness of treatments of inflammatory bowel diseases. The work concludes that there has been an increase in the development of CDDS in which pH, specific enzymes, reactive oxygen species (ROS), or a combination of all of these triggers the release. These delivery systems demonstrated a therapeutic improvement with fewer adverse effects. Future perspectives to the treatment of this disease include the elucidation of molecular basis of IBD diseases in order to design more specific treatments, and the performance of more in vivo assays to validate the specificity and stability of the obtained systems.
Keywords: intestinal permeability; colon; drug delivery; inflammatory bowel diseases intestinal permeability; colon; drug delivery; inflammatory bowel diseases
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MDPI and ACS Style

Teruel, A.H.; Gonzalez-Alvarez, I.; Bermejo, M.; Merino, V.; Marcos, M.D.; Sancenon, F.; Gonzalez-Alvarez, M.; Martinez-Mañez, R. New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy. Int. J. Mol. Sci. 2020, 21, 6502. https://doi.org/10.3390/ijms21186502

AMA Style

Teruel AH, Gonzalez-Alvarez I, Bermejo M, Merino V, Marcos MD, Sancenon F, Gonzalez-Alvarez M, Martinez-Mañez R. New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy. International Journal of Molecular Sciences. 2020; 21(18):6502. https://doi.org/10.3390/ijms21186502

Chicago/Turabian Style

Teruel, Adrian H., Isabel Gonzalez-Alvarez, Marival Bermejo, Virginia Merino, Maria Dolores Marcos, Felix Sancenon, Marta Gonzalez-Alvarez, and Ramon Martinez-Mañez. 2020. "New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy" International Journal of Molecular Sciences 21, no. 18: 6502. https://doi.org/10.3390/ijms21186502

APA Style

Teruel, A. H., Gonzalez-Alvarez, I., Bermejo, M., Merino, V., Marcos, M. D., Sancenon, F., Gonzalez-Alvarez, M., & Martinez-Mañez, R. (2020). New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy. International Journal of Molecular Sciences, 21(18), 6502. https://doi.org/10.3390/ijms21186502

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