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Article

Characteristics of a Series of Three Bacteriophages Infecting Salmonella enterica Strains

1
Laboratory of Molecular Biology, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Kładki 24, 80-822 Gdansk, Poland
2
Department of Molecular Biology, University of Gdansk, Wita Stwosza 59, 80-308 Gdansk, Poland
3
Institute of Oceanology, Polish Academy of Sciences, Powstańców Warszawy 55, 81-712 Sopot, Poland
4
Department of Molecular Evolution, University of Gdansk, Wita Stwosza 59, 80-308 Gdansk, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(17), 6152; https://doi.org/10.3390/ijms21176152
Received: 19 July 2020 / Revised: 18 August 2020 / Accepted: 25 August 2020 / Published: 26 August 2020
(This article belongs to the Special Issue Bacteriophage—Molecular Studies 2.0)
Molecular and functional characterization of a series of three bacteriophages, vB_SenM-1, vB_SenM-2, and vB_SenS-3, infecting various Salmonella enterica serovars and strains is presented. All these phages were able to develop lytically while not forming prophages. Moreover, they were able to survive at pH 3. The phages revealed different host ranges within serovars and strains of S. enterica, different adsorption rates on host cells, and different lytic growth kinetics at various temperatures (in the range of 25 to 42 °C). They efficiently reduced the number of cells in the bacterial biofilm and decreased the biofilm mass. Whole genome sequences of these phages have been determined and analyzed, including their phylogenetic relationships. In conclusion, we have demonstrated detailed characterization of a series of three bacteriophages, vB_SenM-1, vB_SenM-2, and vB_SenS-3, which reveal favorable features in light of their potential use in phage therapy of humans and animals, as well as for food protection purposes. View Full-Text
Keywords: bacteriophages; Salmonella; lytic development; genomic analysis bacteriophages; Salmonella; lytic development; genomic analysis
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MDPI and ACS Style

Kosznik-Kwaśnicka, K.; Ciemińska, K.; Grabski, M.; Grabowski, Ł.; Górniak, M.; Jurczak-Kurek, A.; Węgrzyn, G.; Węgrzyn, A. Characteristics of a Series of Three Bacteriophages Infecting Salmonella enterica Strains. Int. J. Mol. Sci. 2020, 21, 6152. https://doi.org/10.3390/ijms21176152

AMA Style

Kosznik-Kwaśnicka K, Ciemińska K, Grabski M, Grabowski Ł, Górniak M, Jurczak-Kurek A, Węgrzyn G, Węgrzyn A. Characteristics of a Series of Three Bacteriophages Infecting Salmonella enterica Strains. International Journal of Molecular Sciences. 2020; 21(17):6152. https://doi.org/10.3390/ijms21176152

Chicago/Turabian Style

Kosznik-Kwaśnicka, Katarzyna, Karolina Ciemińska, Michał Grabski, Łukasz Grabowski, Marcin Górniak, Agata Jurczak-Kurek, Grzegorz Węgrzyn, and Alicja Węgrzyn. 2020. "Characteristics of a Series of Three Bacteriophages Infecting Salmonella enterica Strains" International Journal of Molecular Sciences 21, no. 17: 6152. https://doi.org/10.3390/ijms21176152

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