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Glucagon-Induced Acetylation of Energy-Sensing Factors in Control of Hepatic Metabolism

Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(8), 1885;
Received: 18 March 2019 / Revised: 4 April 2019 / Accepted: 10 April 2019 / Published: 16 April 2019
(This article belongs to the Special Issue The Biology and Pharmacology of Glucagon)
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The liver is the central organ of glycolipid metabolism, which regulates the metabolism of lipids and glucose to maintain energy homeostasis upon alterations of physiological conditions. Researchers formerly focused on the phosphorylation of glucagon in controlling liver metabolism. Noteworthily, emerging evidence has shown glucagon could additionally induce acetylation to control hepatic metabolism in response to different physiological states. Through inducing acetylation of complex metabolic networks, glucagon interacts extensively with various energy-sensing factors in shifting from glucose metabolism to lipid metabolism during prolonged fasting. In addition, glucagon-induced acetylation of different energy-sensing factors is involved in the advancement of nonalcoholic fatty liver disease (NAFLD) to liver cancer. Here, we summarize the latest findings on glucagon to control hepatic metabolism by inducing acetylation of energy-sensing factors. Finally, we summarize and discuss the potential impact of glucagon on the treatment of liver diseases. View Full-Text
Keywords: glucagon; acetylation; deacetylation; energy-sensing factors; hepatic metabolism glucagon; acetylation; deacetylation; energy-sensing factors; hepatic metabolism

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Zhang, L.; Yao, W.; Xia, J.; Wang, T.; Huang, F. Glucagon-Induced Acetylation of Energy-Sensing Factors in Control of Hepatic Metabolism. Int. J. Mol. Sci. 2019, 20, 1885.

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