Next Article in Journal
Are Circulating Cytokines Reliable Biomarkers for Amyotrophic Lateral Sclerosis?
Next Article in Special Issue
The Role of Epigenetics in Placental Development and the Etiology of Preeclampsia
Previous Article in Journal
The Role of Extracellular Vesicles in Cutaneous Remodeling and Hair Follicle Dynamics
Previous Article in Special Issue
Current Understanding of Autophagy in Pregnancy
Article Menu
Issue 11 (June-1) cover image

Export Article

Open AccessReview

The Role of Nitric Oxide, ADMA, and Homocysteine in The Etiopathogenesis of Preeclampsia—Review

Department of Obstetrics and Perinatology, Medical University of Lublin, Poland, 20-950 Lublin, Jaczewskiego 8, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(11), 2757; https://doi.org/10.3390/ijms20112757
Received: 19 May 2019 / Revised: 27 May 2019 / Accepted: 28 May 2019 / Published: 5 June 2019
(This article belongs to the Special Issue Molecular and Cellular Mechanisms of Preeclampsia)
  |  
PDF [668 KB, uploaded 5 June 2019]
  |  

Abstract

Preeclampsia is a serious, pregnancy-specific, multi-organ disease process of compound aetiology. It affects 3–6% of expecting mothers worldwide and it persists as a leading cause of maternal and foetal morbidity and mortality. In fact, hallmark features of preeclampsia (PE) result from vessel involvement and demonstrate maternal endothelium as a target tissue. Growing evidence suggests that chronic placental hypoperfusion triggers the production and release of certain agents that are responsible for endothelial activation and injury. In this review, we will present the latest findings on the role of nitric oxide, asymmetric dimethylarginine (ADMA), and homocysteine in the etiopathogenesis of preeclampsia and their possible clinical implications. View Full-Text
Keywords: preeclampsia; asymmetric dimethylarginine; nitric oxide; homocysteine preeclampsia; asymmetric dimethylarginine; nitric oxide; homocysteine
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Dymara-Konopka, W.; Laskowska, M. The Role of Nitric Oxide, ADMA, and Homocysteine in The Etiopathogenesis of Preeclampsia—Review. Int. J. Mol. Sci. 2019, 20, 2757.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top