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The Role of Nitric Oxide, ADMA, and Homocysteine in The Etiopathogenesis of Preeclampsia—Review

Department of Obstetrics and Perinatology, Medical University of Lublin, Poland, 20-950 Lublin, Jaczewskiego 8, Poland
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(11), 2757;
Received: 19 May 2019 / Revised: 27 May 2019 / Accepted: 28 May 2019 / Published: 5 June 2019
(This article belongs to the Special Issue Molecular and Cellular Mechanisms of Preeclampsia)
PDF [668 KB, uploaded 5 June 2019]


Preeclampsia is a serious, pregnancy-specific, multi-organ disease process of compound aetiology. It affects 3–6% of expecting mothers worldwide and it persists as a leading cause of maternal and foetal morbidity and mortality. In fact, hallmark features of preeclampsia (PE) result from vessel involvement and demonstrate maternal endothelium as a target tissue. Growing evidence suggests that chronic placental hypoperfusion triggers the production and release of certain agents that are responsible for endothelial activation and injury. In this review, we will present the latest findings on the role of nitric oxide, asymmetric dimethylarginine (ADMA), and homocysteine in the etiopathogenesis of preeclampsia and their possible clinical implications. View Full-Text
Keywords: preeclampsia; asymmetric dimethylarginine; nitric oxide; homocysteine preeclampsia; asymmetric dimethylarginine; nitric oxide; homocysteine

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Dymara-Konopka, W.; Laskowska, M. The Role of Nitric Oxide, ADMA, and Homocysteine in The Etiopathogenesis of Preeclampsia—Review. Int. J. Mol. Sci. 2019, 20, 2757.

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