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Open AccessArticle

Comparative Analysis between the In Vivo Biodistribution and Therapeutic Efficacy of Adipose-Derived Mesenchymal Stromal Cells Administered Intraperitoneally in Experimental Colitis

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Division of Hematopoietic Innovative Therapies, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT) and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER-ISCIII), Avda, Complutense, 40, 28040 Madrid, Spain
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Advanced Therapy Unit, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, (IIS-FJD/UAM), Avda, Complutense, 40, 28040 Madrid, Spain
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TiGenix SAU, Calle de Marconi, 1, 28760 Tres Cantos, Madrid, Spain
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Gene Regulation in Cardiovascular Remodeling and Inflammation Laboratory, CNIC, Calle de Melchor Fernández Almagro, 3, 28029 Madrid, Spain
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Laboratory of Molecular Immunology, The Rockefeller University, 1230 York Avenue, NY 10065, USA
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TiGenix NV, Romeinse straat 12, 3001 Leuven, Belgium
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Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(7), 1853; https://doi.org/10.3390/ijms19071853
Received: 4 June 2018 / Revised: 15 June 2018 / Accepted: 19 June 2018 / Published: 23 June 2018
(This article belongs to the Special Issue Adipose Stem Cells)
Mesenchymal stem cells (MSCs) have emerged as a promising treatment for inflammatory diseases. The immunomodulatory effect of MSCs takes place both by direct cell-to-cell contact and by means of soluble factors that leads to an increased accumulation of regulatory immune cells at the sites of inflammation. Similar efficacy of MSCs has been described regardless of the route of administration used, the inflammation conditions and the major histocompatibility complex context. These observations raise the question of whether the migration of the MSCs to the inflamed tissues is a pre-requisite to achieve their beneficial effect. To address this, we examined the biodistribution and the efficacy of intraperitoneal luciferase-expressing human expanded adipose-derived stem cells (Luci-eASCs) in a mouse model of colitis. Luci-eASC-infused mice were stratified according to their response to the Luci-eASC treatment. According to the stratification criteria, there was a tendency to increase the bioluminescence signal in the intestine at the expense of a decrease in the bioluminescence signal in the liver in the “responder” mice. These data thus suggest that the accumulation of the eASCs to the inflamed tissues is beneficial for achieving an optimal modulation of inflammation. View Full-Text
Keywords: adipose-derived mesenchymal stem cells; intraperitoneal therapy; biodistribution; efficacy; colitis adipose-derived mesenchymal stem cells; intraperitoneal therapy; biodistribution; efficacy; colitis
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Lopez-Santalla, M.; Mancheño-Corvo, P.; Escolano, A.; Menta, R.; Delarosa, O.; Redondo, J.M.; Bueren, J.A.; Dalemans, W.; Lombardo, E.; Garin, M.I. Comparative Analysis between the In Vivo Biodistribution and Therapeutic Efficacy of Adipose-Derived Mesenchymal Stromal Cells Administered Intraperitoneally in Experimental Colitis. Int. J. Mol. Sci. 2018, 19, 1853.

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