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Volume 19
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10.3390/ijms19061777
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Review

Nuclear Receptor Regulation of Aquaglyceroporins in Metabolic Organs

by
Matteo Tardelli
,
Thierry Claudel
,
Francesca Virginia Bruschi
and
Michael Trauner
*
Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology & Hepatology, Internal Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(6), 1777; https://doi.org/10.3390/ijms19061777
Submission received: 16 May 2018 / Revised: 12 June 2018 / Accepted: 13 June 2018 / Published: 15 June 2018
(This article belongs to the Special Issue Molecular Biology of Nuclear Receptors)
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Abstract

Nuclear receptors, such as the farnesoid X receptor (FXR) and the peroxisome proliferator-activated receptors gamma and alpha (PPAR-γ, -α), are major metabolic regulators in adipose tissue and the liver, where they govern lipid, glucose, and bile acid homeostasis, as well as inflammatory cascades. Glycerol and free fatty acids are the end products of lipid droplet catabolism driven by PPARs. Aquaporins (AQPs), a family of 13 small transmembrane proteins, facilitate the shuttling of water, urea, and/or glycerol. The peculiar role of AQPs in glycerol transport makes them pivotal targets in lipid metabolism, especially considering their tissue-specific regulation by the nuclear receptors PPARγ and PPARα. Here, we review the role of nuclear receptors in the regulation of glycerol shuttling in liver and adipose tissue through the function and expression of AQPs.
Keywords: aquaporins; nuclear receptors; glycerol; metabolism aquaporins; nuclear receptors; glycerol; metabolism

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MDPI and ACS Style

Tardelli, M.; Claudel, T.; Bruschi, F.V.; Trauner, M. Nuclear Receptor Regulation of Aquaglyceroporins in Metabolic Organs. Int. J. Mol. Sci. 2018, 19, 1777. https://doi.org/10.3390/ijms19061777

AMA Style

Tardelli M, Claudel T, Bruschi FV, Trauner M. Nuclear Receptor Regulation of Aquaglyceroporins in Metabolic Organs. International Journal of Molecular Sciences. 2018; 19(6):1777. https://doi.org/10.3390/ijms19061777

Chicago/Turabian Style

Tardelli, Matteo, Thierry Claudel, Francesca Virginia Bruschi, and Michael Trauner. 2018. "Nuclear Receptor Regulation of Aquaglyceroporins in Metabolic Organs" International Journal of Molecular Sciences 19, no. 6: 1777. https://doi.org/10.3390/ijms19061777

APA Style

Tardelli, M., Claudel, T., Bruschi, F. V., & Trauner, M. (2018). Nuclear Receptor Regulation of Aquaglyceroporins in Metabolic Organs. International Journal of Molecular Sciences, 19(6), 1777. https://doi.org/10.3390/ijms19061777

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