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Treatment, Therapy and Management of Metabolic Epilepsy: A Systematic Review

Neuropharmacology Research Laboratory, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, 47500 Subang Jaya, Selangor, Malaysia
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Int. J. Mol. Sci. 2018, 19(3), 871; https://doi.org/10.3390/ijms19030871
Received: 20 February 2018 / Revised: 13 March 2018 / Accepted: 13 March 2018 / Published: 15 March 2018
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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Abstract

Metabolic epilepsy is a metabolic abnormality which is associated with an increased risk of epilepsy development in affected individuals. Commonly used antiepileptic drugs are typically ineffective against metabolic epilepsy as they do not address its root cause. Presently, there is no review available which summarizes all the treatment options for metabolic epilepsy. Thus, we systematically reviewed literature which reported on the treatment, therapy and management of metabolic epilepsy from four databases, namely PubMed, Springer, Scopus and ScienceDirect. After applying our inclusion and exclusion criteria as per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we reviewed a total of 43 articles. Based on the reviewed articles, we summarized the methods used for the treatment, therapy and management of metabolic epilepsy. These methods were tailored to address the root causes of the metabolic disturbances rather than targeting the epilepsy phenotype alone. Diet modification and dietary supplementation, alone or in combination with antiepileptic drugs, are used in tackling the different types of metabolic epilepsy. Identification, treatment, therapy and management of the underlying metabolic derangements can improve behavior, cognitive function and reduce seizure frequency and/or severity in patients. View Full-Text
Keywords: metabolic epilepsy; metabolic disorders; antiepileptic drugs; dietary therapy; seizures; cognitive function metabolic epilepsy; metabolic disorders; antiepileptic drugs; dietary therapy; seizures; cognitive function
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Lin Lin Lee, V.; Kar Meng Choo, B.; Chung, Y.-S.; P. Kundap, U.; Kumari, Y.; Shaikh, M.F. Treatment, Therapy and Management of Metabolic Epilepsy: A Systematic Review. Int. J. Mol. Sci. 2018, 19, 871.

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