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Review

Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach

by
Lian Chen
1 and
Hengmin Cui
1,2,*
1
Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Ya’an 625014, China
2
College of Veterinary Medicine, Sichuan Agricultural University, Ya’an 625014, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2015, 16(9), 22830-22855; https://doi.org/10.3390/ijms160922830
Submission received: 23 August 2015 / Revised: 11 September 2015 / Accepted: 15 September 2015 / Published: 22 September 2015
(This article belongs to the Collection Programmed Cell Death and Apoptosis)
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Abstract

Glutamine metabolism has been proved to be dysregulated in many cancer cells, and is essential for proliferation of most cancer cells, which makes glutamine an appealing target for cancer therapy. In order to be well used by cells, glutamine must be transported to cells by specific transporters and converted to glutamate by glutaminase. There are currently several drugs that target glutaminase under development or clinical trials. Also, glutamine metabolism restriction has been proved to be effective in inhibiting tumor growth both in vivo and vitro through inducing apoptosis, growth arrest and/or autophagy. Here, we review recent researches about glutamine metabolism in cancer, and cell death induced by targeting glutamine, and their potential roles in cancer therapy.
Keywords: glutamine metabolism; apoptosis; glutaminase; cancer glutamine metabolism; apoptosis; glutaminase; cancer
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MDPI and ACS Style

Chen, L.; Cui, H. Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach. Int. J. Mol. Sci. 2015, 16, 22830-22855. https://doi.org/10.3390/ijms160922830

AMA Style

Chen L, Cui H. Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach. International Journal of Molecular Sciences. 2015; 16(9):22830-22855. https://doi.org/10.3390/ijms160922830

Chicago/Turabian Style

Chen, Lian, and Hengmin Cui. 2015. "Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach" International Journal of Molecular Sciences 16, no. 9: 22830-22855. https://doi.org/10.3390/ijms160922830

APA Style

Chen, L., & Cui, H. (2015). Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach. International Journal of Molecular Sciences, 16(9), 22830-22855. https://doi.org/10.3390/ijms160922830

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