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Article

Genetic Variants in Human Leukocyte Antigen-DP Influence Both Hepatitis C Virus Persistence and Hepatitis C Virus F Protein Generation in the Chinese Han Population

1
Department of Biochemistry and Molecular Biology, School of Basic Medicine, Nanjing Medical University, Nanjing 210029, China
2
National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University Clinical School of Medicine, Nanjing 210002, China
3
School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China
4
Department of Infectious Diseases, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China
5
Institute of Disease Control and Prevention, Huadong Research Institute for Medicine and Biotechnics, Nanjing 210002, China
6
Department of Clinical Laboratory, Nanjing Second Hospital, Nanjing 210003, China
7
Department of Pharmacology, Nantong University Medical College, Nantong 226019, China
8
School of Life Science and Chemical Engineering, Huaiyin Institute of Technology, Huaian 223003, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2014, 15(6), 9826-9843; https://doi.org/10.3390/ijms15069826
Received: 3 March 2014 / Revised: 19 May 2014 / Accepted: 21 May 2014 / Published: 3 June 2014
(This article belongs to the Special Issue Molecular Bases of Cancer Research)
Chronic hepatitis C is a serious liver disease that often results in cirrhosis or hepatocellular carcinoma. The aim of this study was to assess the association of human leukocyte antigen-DP (HLA-DP) variants with risk of chronic hepatitis C virus (HCV) or anti-F antibody generation. We selected two single nucleotide polymorphisms (SNPs) in a region including HLA-DPA1 (rs3077) and HLA-DPB1 (rs9277534) and genotyped SNPs in 702 cases and 342 healthy controls from the Chinese population using TaqMan SNP genotyping assay. Moreover, the exon 2 of the HLA-DPA1 and HLA-DPB1 genes were amplified and determined by sequencing-based typing (SBT). The results showed that rs3077 significantly increased the risk of chronic HCV infection in additive models and dominant models (odds ratio (OR) = 1.32 and 1.53). The rs3077 also contributed to decrease the risk of anti-F antibody generation in additive models and dominant models (OR = 0.46 and 0.56). Subsequent analyses revealed the risk haplotypes (DPA1*0103-DPB1*0501 and DPA1*0103-DPB1*0201) and protective haplotypes (DPA1*0202-DPB1*0501 and DPA1*0202-DPB1*0202) to chronic HCV infection. Moreover, we also found that the haplotype of DPA1*0103-DPB1*0201 and DPA1*0202-DPB1*0202 were associated with the anti-F antibody generation. Our findings show that genetic variants in HLA-DP gene are associated with chronic HCV infection and anti-F antibody generation. View Full-Text
Keywords: F protein; hepatitis C virus; human leukocyte antigen-DP; polymorphism F protein; hepatitis C virus; human leukocyte antigen-DP; polymorphism
MDPI and ACS Style

Xu, X.; Yue, M.; Jiang, L.; Deng, X.; Zhang, Y.; Zhang, Y.; Zhu, D.; Xiao, W.; Zhou, Z.; Yao, W.; Kong, J.; Yu, X.; Wei, J. Genetic Variants in Human Leukocyte Antigen-DP Influence Both Hepatitis C Virus Persistence and Hepatitis C Virus F Protein Generation in the Chinese Han Population. Int. J. Mol. Sci. 2014, 15, 9826-9843. https://doi.org/10.3390/ijms15069826

AMA Style

Xu X, Yue M, Jiang L, Deng X, Zhang Y, Zhang Y, Zhu D, Xiao W, Zhou Z, Yao W, Kong J, Yu X, Wei J. Genetic Variants in Human Leukocyte Antigen-DP Influence Both Hepatitis C Virus Persistence and Hepatitis C Virus F Protein Generation in the Chinese Han Population. International Journal of Molecular Sciences. 2014; 15(6):9826-9843. https://doi.org/10.3390/ijms15069826

Chicago/Turabian Style

Xu, Xiaodong; Yue, Ming; Jiang, Longfeng; Deng, Xiaozhao; Zhang, Yongxiang; Zhang, Yun; Zhu, Danyan; Xiao, Wen; Zhou, Zhenxian; Yao, Wenjuan; Kong, Jing; Yu, Xiaojie; Wei, Juan. 2014. "Genetic Variants in Human Leukocyte Antigen-DP Influence Both Hepatitis C Virus Persistence and Hepatitis C Virus F Protein Generation in the Chinese Han Population" Int. J. Mol. Sci. 15, no. 6: 9826-9843. https://doi.org/10.3390/ijms15069826

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