Next Article in Journal
Qualitative Analysis of the Helical Electronic Energy of Inherently Chiral Calix[4]arenes: An Approach to Effectively Assign Their Absolute Configuration
Previous Article in Journal
Inhibitors of Acetylcholinesterase and Butyrylcholinesterase Meet Immunity
Previous Article in Special Issue
Nipple Discharge of CA15-3, CA125, CEA and TSGF as a New Biomarker Panel for Breast Cancer
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 15
Issue 6
10.3390/ijms15069826
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Genetic Variants in Human Leukocyte Antigen-DP Influence Both Hepatitis C Virus Persistence and Hepatitis C Virus F Protein Generation in the Chinese Han Population

by
Xiaodong Xu
1,2,†,
Ming Yue
3,†,
Longfeng Jiang
4,†,
Xiaozhao Deng
1,5,*,
Yongxiang Zhang
4,*,
Yun Zhang
5,*,
Danyan Zhu
1,
Wen Xiao
3,
Zhenxian Zhou
6,
Wenjuan Yao
7,
Jing Kong
8,
Xiaojie Yu
1 and
Juan Wei
1
1
Department of Biochemistry and Molecular Biology, School of Basic Medicine, Nanjing Medical University, Nanjing 210029, China
2
National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University Clinical School of Medicine, Nanjing 210002, China
3
School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China
4
Department of Infectious Diseases, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China
5
Institute of Disease Control and Prevention, Huadong Research Institute for Medicine and Biotechnics, Nanjing 210002, China
6
Department of Clinical Laboratory, Nanjing Second Hospital, Nanjing 210003, China
7
Department of Pharmacology, Nantong University Medical College, Nantong 226019, China
8
School of Life Science and Chemical Engineering, Huaiyin Institute of Technology, Huaian 223003, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2014, 15(6), 9826-9843; https://doi.org/10.3390/ijms15069826
Submission received: 3 March 2014 / Revised: 19 May 2014 / Accepted: 21 May 2014 / Published: 3 June 2014
(This article belongs to the Special Issue Molecular Bases of Cancer Research)
Versions Notes

Abstract

Chronic hepatitis C is a serious liver disease that often results in cirrhosis or hepatocellular carcinoma. The aim of this study was to assess the association of human leukocyte antigen-DP (HLA-DP) variants with risk of chronic hepatitis C virus (HCV) or anti-F antibody generation. We selected two single nucleotide polymorphisms (SNPs) in a region including HLA-DPA1 (rs3077) and HLA-DPB1 (rs9277534) and genotyped SNPs in 702 cases and 342 healthy controls from the Chinese population using TaqMan SNP genotyping assay. Moreover, the exon 2 of the HLA-DPA1 and HLA-DPB1 genes were amplified and determined by sequencing-based typing (SBT). The results showed that rs3077 significantly increased the risk of chronic HCV infection in additive models and dominant models (odds ratio (OR) = 1.32 and 1.53). The rs3077 also contributed to decrease the risk of anti-F antibody generation in additive models and dominant models (OR = 0.46 and 0.56). Subsequent analyses revealed the risk haplotypes (DPA1*0103-DPB1*0501 and DPA1*0103-DPB1*0201) and protective haplotypes (DPA1*0202-DPB1*0501 and DPA1*0202-DPB1*0202) to chronic HCV infection. Moreover, we also found that the haplotype of DPA1*0103-DPB1*0201 and DPA1*0202-DPB1*0202 were associated with the anti-F antibody generation. Our findings show that genetic variants in HLA-DP gene are associated with chronic HCV infection and anti-F antibody generation.
Keywords: F protein; hepatitis C virus; human leukocyte antigen-DP; polymorphism F protein; hepatitis C virus; human leukocyte antigen-DP; polymorphism

Share and Cite

MDPI and ACS Style

Xu, X.; Yue, M.; Jiang, L.; Deng, X.; Zhang, Y.; Zhang, Y.; Zhu, D.; Xiao, W.; Zhou, Z.; Yao, W.; et al. Genetic Variants in Human Leukocyte Antigen-DP Influence Both Hepatitis C Virus Persistence and Hepatitis C Virus F Protein Generation in the Chinese Han Population. Int. J. Mol. Sci. 2014, 15, 9826-9843. https://doi.org/10.3390/ijms15069826

AMA Style

Xu X, Yue M, Jiang L, Deng X, Zhang Y, Zhang Y, Zhu D, Xiao W, Zhou Z, Yao W, et al. Genetic Variants in Human Leukocyte Antigen-DP Influence Both Hepatitis C Virus Persistence and Hepatitis C Virus F Protein Generation in the Chinese Han Population. International Journal of Molecular Sciences. 2014; 15(6):9826-9843. https://doi.org/10.3390/ijms15069826

Chicago/Turabian Style

Xu, Xiaodong, Ming Yue, Longfeng Jiang, Xiaozhao Deng, Yongxiang Zhang, Yun Zhang, Danyan Zhu, Wen Xiao, Zhenxian Zhou, Wenjuan Yao, and et al. 2014. "Genetic Variants in Human Leukocyte Antigen-DP Influence Both Hepatitis C Virus Persistence and Hepatitis C Virus F Protein Generation in the Chinese Han Population" International Journal of Molecular Sciences 15, no. 6: 9826-9843. https://doi.org/10.3390/ijms15069826

APA Style

Xu, X., Yue, M., Jiang, L., Deng, X., Zhang, Y., Zhang, Y., Zhu, D., Xiao, W., Zhou, Z., Yao, W., Kong, J., Yu, X., & Wei, J. (2014). Genetic Variants in Human Leukocyte Antigen-DP Influence Both Hepatitis C Virus Persistence and Hepatitis C Virus F Protein Generation in the Chinese Han Population. International Journal of Molecular Sciences, 15(6), 9826-9843. https://doi.org/10.3390/ijms15069826

Article Metrics

Back to TopTop