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Volume 31
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10.3390/molecules31010098
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

Recent Advances in Ent-Abietane Diterpenes: Natural Sources, Biological Activities and Total Synthesis

by
Lu Li
1,†,
Yongjie Zhu
1,†,
Haixia Deng
1,
Liqiong Xie
1,
Chang-Bo Zheng
1,2,
Jian-Neng Yao
1,2,* and
Ji Li
1,2,*
1
School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China
2
Yunnan College of Modern Biomedical Industry, Kunming Medical University, Kunming 650500, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Molecules 2026, 31(1), 98; https://doi.org/10.3390/molecules31010098 (registering DOI)
Submission received: 1 December 2025 / Revised: 19 December 2025 / Accepted: 22 December 2025 / Published: 25 December 2025
(This article belongs to the Special Issue Trends of Drug Synthesis in Medicinal Chemistry)
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Abstract

Ent-abietane diterpenoids constitute a class of terpenes with a C20 carbon skeleton that underlie a wide range of biological activities. Ent-abietane diterpenoids, enantiomeric to the abietane counterparts, represent a family of diterpenoid natural products characterized by their distinct 6/6/6 tricyclic carbocyclic skeletons with exceptional structural complexity. An increasing number of these ent-abietane diterpenoids have recently been identified, constituting a well-defined group of naturally occurring compounds. This review provides a comprehensive summary of the natural sources, chemical structures, biological profiles and total synthesis of these ent-abietane diterpenoids from 2016 to early 2025.
Keywords: ent-abietane diterpenoid; isolation; structure elucidation; biological activities; total synthesis; natural products ent-abietane diterpenoid; isolation; structure elucidation; biological activities; total synthesis; natural products
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MDPI and ACS Style

Li, L.; Zhu, Y.; Deng, H.; Xie, L.; Zheng, C.-B.; Yao, J.-N.; Li, J. Recent Advances in Ent-Abietane Diterpenes: Natural Sources, Biological Activities and Total Synthesis. Molecules 2026, 31, 98. https://doi.org/10.3390/molecules31010098

AMA Style

Li L, Zhu Y, Deng H, Xie L, Zheng C-B, Yao J-N, Li J. Recent Advances in Ent-Abietane Diterpenes: Natural Sources, Biological Activities and Total Synthesis. Molecules. 2026; 31(1):98. https://doi.org/10.3390/molecules31010098

Chicago/Turabian Style

Li, Lu, Yongjie Zhu, Haixia Deng, Liqiong Xie, Chang-Bo Zheng, Jian-Neng Yao, and Ji Li. 2026. "Recent Advances in Ent-Abietane Diterpenes: Natural Sources, Biological Activities and Total Synthesis" Molecules 31, no. 1: 98. https://doi.org/10.3390/molecules31010098

APA Style

Li, L., Zhu, Y., Deng, H., Xie, L., Zheng, C.-B., Yao, J.-N., & Li, J. (2026). Recent Advances in Ent-Abietane Diterpenes: Natural Sources, Biological Activities and Total Synthesis. Molecules, 31(1), 98. https://doi.org/10.3390/molecules31010098

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