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Article

Multi-Target Strategy to Uncover Unexpected Compounds in Rinse-Off and Leave-On Cosmetics

Department of Analytical Chemistry, Nutrition and Food Science, Faculty of Chemistry, CRETUS Institute, Universidade de Santiago de Compostela, E-15782 Santiago de Compostela, Spain
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Author to whom correspondence should be addressed.
Academic Editor: Elena Falqué López
Molecules 2021, 26(9), 2504; https://doi.org/10.3390/molecules26092504
Received: 9 April 2021 / Revised: 22 April 2021 / Accepted: 23 April 2021 / Published: 25 April 2021
(This article belongs to the Special Issue Last Advances in Cosmetics and Personal Care Products Analysis)
The wide range and complexity of cosmetic formulations currently available on the market poses a challenge from an analytical point of view. In addition, during cosmetics manufacture, impurities coming from raw materials or formed by reaction of different organic compounds present in the formulation may be present. Their identification is mandatory to assure product quality and consumer health. In this work, micro-matrix solid-phase dispersion (μMSPD) is proposed as a multi-target sample preparation strategy to analyze a wide number of unexpected families of compounds including polycyclic aromatic hydrocarbons (PAHs), pesticides, plasticizers, nitrosamines, alkylphenols (APs), and alkylphenol ethoxylates (APEOs). Analytical determination was performed by gas chromatography-mass spectrometry (GC-MS) for the determination of 51 target compounds in a single run, whereas liquid chromatography tandem mass spectrometry (LC-MS/MS) was employed for the analysis of six APs and APEOs. Both methodologies were successfully validated in terms of linearity, accuracy, and precision in leave-on and rinse-off cosmetics. Limits of detection (LODs) were calculated in the low ng g−1, showing their suitability to determine trace levels of impurities and banned compounds with different chemical natures, providing useful tools to cosmetic control laboratories and companies. View Full-Text
Keywords: cosmetics analysis; banned compounds; polycyclic aromatic hydrocarbons; pesticides; nitrosamines; alkylphenol ethoxylates; miniaturized sample preparation; gas chromatography; liquid chromatography; mass spectrometry cosmetics analysis; banned compounds; polycyclic aromatic hydrocarbons; pesticides; nitrosamines; alkylphenol ethoxylates; miniaturized sample preparation; gas chromatography; liquid chromatography; mass spectrometry
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MDPI and ACS Style

Celeiro, M.; Rubio, L.; Garcia-Jares, C.; Lores, M. Multi-Target Strategy to Uncover Unexpected Compounds in Rinse-Off and Leave-On Cosmetics. Molecules 2021, 26, 2504. https://doi.org/10.3390/molecules26092504

AMA Style

Celeiro M, Rubio L, Garcia-Jares C, Lores M. Multi-Target Strategy to Uncover Unexpected Compounds in Rinse-Off and Leave-On Cosmetics. Molecules. 2021; 26(9):2504. https://doi.org/10.3390/molecules26092504

Chicago/Turabian Style

Celeiro, Maria, Laura Rubio, Carmen Garcia-Jares, and Marta Lores. 2021. "Multi-Target Strategy to Uncover Unexpected Compounds in Rinse-Off and Leave-On Cosmetics" Molecules 26, no. 9: 2504. https://doi.org/10.3390/molecules26092504

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